Publications by authors named "N Nissen"
Background And Aims: The change in hepatocellular carcinoma (HCC) care continuum during the coronavirus disease 2019 (COVID-19) pandemic remains unknown at a national level in the United States. We sought to determine the impact of the pandemic on incident HCC cases, clinical characteristics, and treatment in the United States.
Methods: Using the National Cancer Database, we analyzed incident HCC cases from 2010 to 2020.
Article Synopsis
- - The study explores the limited effectiveness of existing interventions for caregivers of cardiac patients, highlighting that most fail to improve caregiver well-being.
- - A literature review was conducted from a range of medical databases to assess these interventions, revealing that they often lack a systematic approach and proper methodological rigor.
- - The findings emphasize the need for more structured and transparent intervention designs, which could enhance support for caregivers and ultimately benefit both caregivers and cardiac patients.
Background: Serum AFP-L3%, AFP, and DCP are useful biomarkers for HCC detection, but their utility in assessing treatment response remains unknown. We aim to evaluate the accuracy of a biomarker model in the detection of posttreatment viable tumors.
Methods: For model derivation, recipients with HCC undergoing liver transplant from 2018 to 2022 who had biomarkers collected within 3 months before transplant were included.
Fibrosis, driven by fibroblast activities, is an important contributor to morbidity and mortality in most chronic diseases. Endotrophin, a signaling molecule derived from processing of type VI collagen by highly activated fibroblasts, is involved in fibrotic tissue remodeling. Circulating levels of endotrophin have been associated with an increased risk of mortality in multiple chronic diseases.
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- The COVID-19 pandemic disrupted access to surveillance and treatments for hepatocellular carcinoma (HCC), leading to underdiagnosis and variable treatment outcomes in the U.S.
- A study analyzing HCC incidence and mortality from 2001 to 2020 found a 12.2% decrease in the age-adjusted incidence rate in 2020 compared to 2019, especially among Black and Hispanic individuals.
- Despite the decrease in diagnosed cases, short-term overall survival and mortality rates for HCC remained stable during this period, highlighting a need for further research on long-term effects.