Publications by authors named "N Nishio"
Chimeric antigen receptor (CAR) T cells are a major new treatment option for children, adolescents, and young adults (CAYA) patients with relapsed and refractory (R/R) B cell acute lymphoblastic leukemia (B-ALL). Therefore, accumulating evidence from real-world experiences of CAR-T outcomes in various regions worldwide is important, particularly when comparing outcomes of patients with differing medical and ethnic backgrounds. More than 5 years have passed since tisagenlecleucel was approved in Japan.
View Article and Find Full Text PDFBackground: In a randomized phase II/III trial (JCOG1008), weekly cisplatin (40 mg/m) was non-inferior to 3-weekly cisplatin (100 mg/m) for postoperative high-risk head and neck cancer. We investigated how acute kidney injury (AKI), a major dose-limiting toxicity effect of cisplatin, affects overall survival (OS).
Methods: We analyzed 251 patients from JCOG1008 receiving chemoradiotherapy.
Article Synopsis
- A deep learning (DL) model using Vision Transformer (ViT) was created to automatically diagnose muscle-invasive bladder cancer (MIBC) from MRI scans.
- The study utilized data from multiple institutions, with a training dataset of 170 patients and a test dataset of 53 patients, comparing the ViT model's performance to conventional convolutional neural networks (CNNs) and radiologists' assessments.
- The results showed that the ViT model significantly outperformed CNNs in diagnostic accuracy, achieving an area under the curve (AUC) of 0.872, which is comparable to that of junior radiologists.
Article Synopsis
- Hypothyroidism is a common late side effect following radiotherapy for head and neck cancer, which the JCOG1008 trial aimed to investigate by analyzing patient data.
- The trial enrolled 261 patients from 28 institutions between 2012 and 2018 and conducted thyroid function tests to identify factors associated with developing hypothyroidism post-treatment.
- Results showed that 16.7% of patients developed hypothyroidism within 2 years, with significant factors being the use of weekly cisplatin and lower baseline free thyroxine levels in those undergoing intensity-modulated radiotherapy.
Allogeneic hematopoietic cell transplantation (HCT) is a crucial treatment for various diseases, including hematological malignancies, solid tumors, and genetic disorders. Despite its curative potential, HCT is associated with severe complications, notably infections, graft-versus-host disease, and organ damage. Infections, particularly bloodstream infections (BSIs), pose a significant threat in the initial weeks post-HCT, necessitating effective management strategies.
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