Publications by authors named "N Nishijima"

Article Synopsis
  • Atezolizumab plus bevacizumab (Atezo/Bev) is the main treatment for advanced hepatocellular carcinoma (HCC), but about 26% of patients don't respond well, indicating a need for better alternatives.
  • A study of 302 HCC patients receiving Atezo/Bev identified key predictors of treatment resistance, focusing specifically on the first-line cohort of 214 patients.
  • The CRAFITY score was identified as a strong predictor of refractoriness, showing that nearly one-third of patients were unresponsive to the therapy, with varied outcomes based on the score.
View Article and Find Full Text PDF

Immune check point inhibitors (ICIs) have durable antitumor effects. However, autoimmune toxicities, termed immune-related adverse events, occur in some patients. We report a case of severe immune aplastic anemia (AA) in a patient with non-small cell lung cancer who was receiving atezolizumab with bevacizumab/carboplatin/paclitaxel.

View Article and Find Full Text PDF

We herein report an autopsy case of streptococcal toxic shock syndrome with disseminated intravascular coagulation and multiple cerebral infarctions induced by Streptococcus dysgalactiae subsp. equisimilis (STSS) in an 84-year-old male. Pathological examination revealed sepsis with hemophagocytosis in the reticular system and intravascular bacteria in multiple organs, originating from bacterial necrotizing fasciitis of the lower extremities.

View Article and Find Full Text PDF

A 74-year-old woman, who had been receiving olaparib for the treatment of ovarian cancer for more than a year, visited the emergency department complaining of a fever that had lasted for 1 month. She had been taking antipyretics and antibiotics for her fever, but without any effect. Although she had no symptoms other than fever, she had stopped taking olaparib for 1 week before her visit because she had developed anemia caused by myelosuppression from olaparib.

View Article and Find Full Text PDF