Publications by authors named "N Nicolas Bonnet"
Purpose Of Review: This review aims to consolidate recent observations regarding extra-osseous roles of the RANK-RANKL-OPG axis, primarily within skeletal muscle.
Recent Findings: Preclinical efforts to decipher a common signalling pathway that links the synchronous decline in bone and muscle health in ageing and disease disclosed a potential role of the RANK-RANKL-OPG axis in skeletal muscle. Evidence suggests RANKL inhibition benefits skeletal muscle function, mass, fibre-type switching, calcium homeostasis and reduces fall incidence.
Article Synopsis
- Lactoferrin (LF) and osteopontin (OPN) are milk proteins that can form complexes, which were studied for their effects on infant digestion and health.
- Pre-clinical models showed that these complexes enhance LF's protective qualities during digestion and improve its impact on gut health.
- In a neonatal rodent model, LF-OPN coacervation promoted better bone structure and increased stiffness, indicating potential benefits for bone development.
Article Synopsis
- Sézary syndrome is a rare and deadly skin cancer, and this study looked into the survival rates and factors affecting outcomes, particularly focusing on the treatment mogamulizumab.
- *The research analyzed data from 339 patients diagnosed between 2000 and 2020 across Europe, highlighting that age over 80 and large-cell transformation worsened survival rates.
- *Results indicated that patients treated with mogamulizumab had significantly lower mortality rates, suggesting it is an effective treatment option for Sézary syndrome.
The present work proposes an extension to the approach of [Xi, C; et al. 6878] to calculate ion solvation free energies from first-principles (FP) molecular dynamics (MD) simulations of a hybrid solvation model. The approach is first re-expressed within the quasi-chemical theory of solvation.
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