Publications by authors named "N Negishi"
Lagrangians of the state-averaged multiconfigurational self-consistent field (SA-MCSCF) and multistate extended second-order quasidegenerate perturbation theory (MS-XMCQDPT2) coupled with the reference interaction site model self-consistent field constraint spatial electron density are defined. In addition, variational equations were derived to calculate the excitation energies of the target molecules dissolved in various solvents. The theory was applied to a phenol molecule in various solutions, and the gradients and Hessian matrices were calculated to evaluate the absorption spectral lines, including the broadening bandwidth.
View Article and Find Full Text PDFWe quantified and subsequently analyzed bandwidth of ultraviolet and visible photoabsorption spectral lines in solution by applying time-dependent first-order perturbation theory using the Born-Oppenheimer adiabatic potential calculated using the multistate extended-multi-configurational quasi-degenerated second-order perturbation theory (MS-XMCQDPT2) coupled with the reference interaction site model self-consistent field spatial electron density distribution (RISM-SCF-cSED). The proposed method was implemented for 2-thiocytosine in solution, and solvatochromism of the bandwidth of the ππ* transition was clearly observed. The standard deviation of a characteristic electronic excitation was decomposed into the contributions of the characteristic vibrational mode of 2-thiocytosine.
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- Researchers developed a method to identify IgE cross-reactive allergens and aimed to understand how these allergens lead to food allergies, specifically by examining the connection between food allergens and house dust mite allergens using a mouse model.
- The study involved using allergenic protein microarray analysis to test the serum of mice that were sensitized with house dust mite extract (Der p) and observed how their IgE responded to coho salmon proteins and other allergens.
- Results showed significant binding of IgE from Der p-sensitized mice to coho salmon proteins, indicating that exposure to coho salmon can trigger allergic reactions like cutaneous anaphylaxis and oral allergy syndrome in these mice.
We developed a high-speed filterless airflow multistage photocatalytic elbow aerosol removal system for the treatment of bioaerosols such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human-generated bioaerosols that diffuse into indoor spaces are 1-10 μm in size, and their selective and rapid treatment can reduce the risk of SARS-CoV-2 infection. A high-speed airflow is necessary to treat large volumes of indoor air over a short period.
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- - T-cell development in the thymus requires Notch signaling activated by the interaction between Notch1 on T-cell precursors and Dll4 on thymic epithelial cells, with Dll4 evolving from a common ancestor of various fish species.
- - Dll1, rather than Dll4, is crucial for T-cell development in cartilaginous fishes, and experiments show that Dll1 can fully compensate for the absence of Dll4 in mouse models, triggering important Notch signaling pathways.
- - The study indicates that Dll1 activates Notch signaling involving Notch1 and Notch2, while Dll4 is restricted to activating only Notch1 in the thymus, suggesting a significant evolutionary shift