Publications by authors named "N Navari"
Article Synopsis
- Research Focus
- : The study investigates how fatty acid metabolism impacts stem-like characteristics in intrahepatic cholangiocarcinoma (iCCA), a serious type of liver cancer.
- Key Findings
- : Cancer cells with stem-like features (SPH) have higher levels of free fatty acids and lipid synthesis enzymes compared to regular cells. Inhibition of fatty acid synthase (FASN) reduces these stem characteristics and tumor growth in lab models.
- Clinical Implications
- : Targeting fatty acid metabolism could provide new strategies for treating iCCA, potentially improving patient survival and slowing disease progression.
Article Synopsis
- Research shows that both Normothermic Regional Perfusion (NRP) and Hypothermic-Oxygenated-Perfusion (HOPE) improve outcomes in liver transplants from donors after circulatory death (DCD), but direct comparisons and mechanisms are not well-studied.
- In a rat study, DCD livers experienced more damage and inflammation after NRP compared to HOPE, which resulted in better mitochondrial health and lower inflammation.
- The findings suggest that high-risk DCD livers benefit more from HOPE, indicating a need for further clinical studies to confirm these results and improve transplant outcomes.
Background & Aims: Cirrhosis and its complications may affect gut microbiota (GM) composition. Transjugular intrahepatic portosystemic shunt (TIPS) represents the most effective treatment for portal hypertension (PH). We aimed to evaluate whether TIPS placement modifies GM composition and metabolic function.
View Article and Find Full Text PDFBackground & Aims: Activation of Kupffer cells and recruitment of monocytes are key events in fibrogenesis. These cells release soluble mediators which induce the activation of hepatic stellate cells (HSCs), the main fibrogenic cell type within the liver. Mer tyrosine kinase (MerTK) signaling regulates multiple processes in macrophages and has been implicated in the pathogenesis of non-alcoholic steatohepatitis-related fibrosis.
View Article and Find Full Text PDFBackground And Aims: Cholangiocarcinoma (CCA) is characterized by high resistance to chemotherapy and poor prognosis. Several oncogenic pathways converge on activation of extracellular signal-regulated kinase 5 (ERK5), whose role in CCA has not been explored. The aim of this study was to investigate the role of ERK5 in the biology of CCA.
View Article and Find Full Text PDF