Publications by authors named "N Nathwani"
Article Synopsis
- The study aimed to compare the clinical characteristics and visual field defects between high-tension glaucoma (HTG) and normal-tension glaucoma (NTG) among patients in the LiGHT China trial.
- A total of 622 patients with open-angle glaucoma were analyzed, revealing that NTG patients tended to be older, predominantly female, and had higher rates of hypertension and ischaemic heart disease compared to HTG patients.
- While both groups showed similar severity in overall visual field defects, NTG exhibited notably greater asymmetry in visual field loss, which was correlated with fluctuations in daytime intraocular pressure.
Importance: Selective laser trabeculoplasty (SLT) is becoming the recommended first choice in the treatment of open-angle glaucoma (OAG). However, whether repeat SLT can be recommended regardless of initial response remains controversial.
Objective: To assess the potential of OAG and ocular hypertension (OHT) undergoing repeat laser to respond favorably to SLT, termed responsiveness to SLT.
Objectives: Cluster of differentiation 38 (CD38) is a key target on multiple myeloma (MM) cells. This multi-centre, Phase 1, single-agent study (NCT04000282) investigated SAR442085, a novel fragment crystallisable (Fc)-modified anti-CD38 monoclonal antibody (mAb), with enhanced affinity towards Fc-gamma receptor on effector cells in patients with relapsed and/or refractory (RR) MM.
Methods: This study comprised two parts: Part-A (dose-escalation involving anti-CD38 mAb pre-treated and naïve patients) and Part-B (dose expansion).