Publications by authors named "N Nakada"
Histopathology
February 2025
Article Synopsis
- The study aimed to evaluate the effectiveness of AI-assisted digital image analysis for assessing Ki-67 levels in invasive breast carcinoma (IBC) by analyzing the accuracy and performance of a deep-learning model.
- Researchers constructed two models (DL-TC and DL-ND) using a large dataset of Ki-67 slide images and found that the models performed well in identifying cancerous tissue and correlating with manual counts of Ki-67.
- The results indicated that higher Ki-67 index levels were associated with poorer patient outcomes, confirming that this AI-based analysis could potentially enhance prognostic assessments in breast cancer.
Pathol Int
September 2024
Article Synopsis
- Identifying CD30 expression through immunohistochemistry is crucial for treating lymphomas with CD30-targeting antibody-drug conjugates, but no standardized staining protocol existed prior to this study.
- The research compared three automated immunostaining platforms (Bond III, Dako Omnis, Ventana BenchMark ULTRA) using varying dilutions of a primary antibody to determine effective staining conditions.
- The study found that adjusting antibody dilutions and cutoff values can achieve consistent CD30 staining across different platforms, with high concordance rates for diagnosing peripheral T-cell lymphomas.
Cancers (Basel)
February 2024
Article Synopsis
- No reliable marker for predicting peritoneal metastasis during chemotherapy for advanced gastric cancer (AGC) currently exists, which complicates treatment effectiveness.
- A study examining 73 AGC patients receiving TAX/RAM therapy found that elevated serum CA125 levels were significantly associated with the presence of peritoneal metastasis, with 80.6% of patients showing increased CA125 levels having this condition.
- The study concluded that monitoring CA125 kinetics can serve as an early indicator of peritoneal metastasis progress in patients undergoing this chemotherapy regimen.
Microbiol Spectr
April 2024
Article Synopsis
- Invasive aspergillosis (IA) and mucormycosis are severe infections predominantly affecting immunocompromised individuals, and drug-resistant strains present a significant clinical challenge.*
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- This research explores the potential of Vγ9Vδ2 T cells, a unique subset of T cells, in fighting these infections, showing strong antifungal properties against resistant strains by direct interaction with fungal hyphae.*
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- The study highlights the promising role of Vγ9Vδ2 T cells as a new therapy for treating IA and mucormycosis, which could offer an effective alternative to traditional antifungal treatments that often have harmful side effects.*
Article Synopsis
- * Out of 672 patients analyzed, only 9 (1.3%) developed complicated NTM infections, leading to a higher mortality rate in those patients compared to others.
- * The findings suggest that while NTM complications are rare among those on biologics, they can be severe, especially in patients taking higher doses of corticosteroids, necessitating vigilant monitoring even in the absence of positive MAC antibody tests.
