Resistance to spindle inhibitors in glioblastoma depends on STAT3 and therapy induced senescence.

While mitotic spindle inhibitors specifically kill proliferating tumor cells without the toxicities of microtubule poisons, resistance has limited their clinical utility. Treating glioblastomas with the spindle inhibitors ispinesib, alisertib, or volasertib creates a subpopulation of therapy induced senescent cells that resist these drugs by relying upon the anti-apoptotic and metabolic effects of activated STAT3. Furthermore, these senescent cells expand the repertoire of cells resistant to these drugs by secreting an array of factors, including TGFβ, which induce proliferating cells to exit mitosis and become quiescent-a state that also resists spindle inhibitors.

Studies on uranium concentration in groundwater samples and its associated health hazards to the residents of surrounding regions of Manchanabele reservoir, Bengaluru, Karnataka, India.

Uranium occurs naturally in groundwater and surface water. Being a radioactive element, high uranium concentration can cause impact on human health. The health effects associated with consumption of uranium through water includes increased cancer risk and kidney toxicity.

Contributions of Prof. P. Venkataramaiah to the research on radiation physics and education in India.

Prof. P. Venkataramaiah (P.

Multifiller-based polymer composites for shielding high energy ionising radiation.

Polydimethyl silicone rubber-based polymer composites filled with molybdenum and bismuth were fabricated using simple open mold cast technique. The physical and chemical structure and gamma shielding parameters like attenuation coefficient, half-value layer (HVL) thickness and relaxation length have been investigated for the said novel materials using X-ray diffraction (XRD), Fourier transform Infrared spectroscopy (FTIR) and gamma ray spectrometer. XRD study reveals the crystalline nature of the composites.

Resistance to Spindle Inhibitors in Glioblastoma Depends on STAT3 and Therapy Induced Senescence.

Unlabelled: While mitotic spindle inhibitors specifically kill proliferating tumor cells without the toxicities of microtubule poisons, resistance has limited their clinical utility. Treating glioblastomas with the spindle inhibitors ispinesib, alisertib, or volasertib creates a subpopulation of therapy induced senescent cells that resist these drugs by relying upon the anti-apoptotic and metabolic effects of activated STAT3. Furthermore, these senescent cells expand the repertoire of cells resistant to these drugs by secreting an array of factors, including TGFβ, which induce proliferating cells to exit mitosis and become quiescent-a state that also resists spindle inhibitors.