Comparison of lactate/albumin ratio to lactate and lactate clearance for predicting outcomes in patients with septic shock admitted to intensive care unit: an observational study.

The aim of this study was to evaluate the prognostic value of the Lactate to Albumin (L/A) ratio compared to that of lactate and lactate clearance in predicting outcomes in patients with septic shock. This was a multi-center observational study of adult patients with septic shock, who admitted to intensive care units (ICUs) at Shohada and Imam Reza Hospitals, Tabriz, Iran, between Sept 2018 and Jan 2021. The area under the curve (AUC) of receiver operating characteristic (ROC) curve and multivariate logistic regression analyses were used to explore associations of the L/A ratio, lactate and lactate clearance on the primary (mortality) and secondary outcomes [ICU length of stay (LOS), duration of mechanical ventilation (MV), need of renal replacement therapy (RRT) and duration of using vasopressors] at baseline, 6 h and 24 h of septic shock recognition.

Volatile anesthetic effects on ischemic myocardium.

Volatile anesthetics, particularly the new generation of agents, have a very rapid onset and offset of action. These properties allow for quick recovery from clinical anesthesia. Because there is additional evidence that these agents have protective effects during myocardial ischemia, there may be advantages for 'fast tracking' patients undergoing coronary revascularization procedures.

Reactive oxygen species contribute to oxygen-related lung injury after acid aspiration.

Unlabelled: Hyperoxia increases pulmonary damage after acid aspiration. We hypothesize that free radicals play a role in acute lung injury. To examine this hypothesis, we injured rats by intratracheal instillation of acidic isotonic sodium chloride solution (NS) (pH 1.