Publications by authors named "N N Zhigalova"
N-methyladenosine (mA) is one of the most common modifications in both eukaryotic and prokaryotic mRNAs. It has been experimentally confirmed that mA methylation is involved in the regulation of stability and translation of various mRNAs. Until recently, the majority of mA-related studies have been focused on the cytoplasmic functions of this modification.
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- During gastrulation and neurulation in vertebrate embryos, the chordamesoderm and neuroectoderm converge and extend under a genetic program.
- This study investigates whether mechanical tension from these movements influences gene expression in these tissues.
- By analyzing stretched midgastrula embryo explants, researchers found that mechanical stretching activates certain genes in the stretched trunk region while inhibiting others in low-stretch areas, suggesting that mechanical forces could regulate embryonic patterning and development.
Kaiso is a methyl DNA binding transcriptional factor involved in cell cycle control, WNT signaling, colon inflammation, and cancer progression. Recently, it was shown that SUMOylation dynamically modulates the transcriptional activity of Kaiso. However, factors involved in SUMOylation of Kaiso are unknown.
View Article and Find Full Text PDFGain and loss of DNA methylation in cells is a dynamic process that tends to achieve an equilibrium. Many factors are involved in maintaining the balance between DNA methylation and demethylation. Previously, it was shown that methyl-DNA protein Kaiso may attract NCoR, SMRT repressive complexes affecting histone modifications.
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- Zyxin is a protein that helps control the structure of the cytoskeleton and gene expression, influencing both cell differentiation and stem cell status.
- When zyxin levels are decreased in Xenopus laevis embryos, it leads to reduced expression of genes that promote differentiation, while increasing the expression of genes linked to stem cell characteristics.
- Specifically, zyxin interacts with the Y-box protein Ybx1 to stabilize certain mRNAs, preventing their degradation, which highlights zyxin's role in regulating the balance between cell movement, differentiation, and maintaining stem cell properties.