Hyaluronic Acid as a LYVE-1 Receptor Ligand in the Lymphatic System of Healthy Human Skin.

Immunohistochemical detection of the LYVE-1 marker in healthy human full-thickness skin (the epidermis and the dermis) was carried out. LYVE-1 expression was found in the endothelium of lymphatic capillaries located in the papillary dermis, in the endothelium of larger lymphatic vessels of the reticular dermis, and in fibroblasts, which indicates their joint participation in hyaluronan metabolism. LYVE-1 staining detected for the first time in cells of the stratum basale, the stratum spinosum, and the stratum granulosum of healthy human epidermis indicates their participation in hyaluronan metabolism and allows us to consider the spaces between epidermis cells as prelimphatics.

[Pathological anatomy and basic stages in pathogenesis of Teutschlander syndrome].

Skin, muscle and fat biopsy of a patient with Teutschlander syndrome was studied with light microscopy. Atrophy, sclerosis and lymphostasis of all layers of the skin with small inorganic crystals, with foreign body granulomas or without inflammatory reaction in papillary and reticular layers were observed. Fat tissue under the skin was completely replaced by masses of extra-cellular lipids.

[Genitography in intersexuality].

Genitography was performed in 60 patients with different sexual abnormalities. The main types of the structure of external and internal genitals were revealed. Genitography can be used in any age, including the 1st year of life.

[Sex and age differences in the peripheral blood aldosterone levels].

Age-associated and sexual differences in the adrenocortical glomerular zone function of normal subjects were studied by radioimmunoassay. The blood plasma aldosterone content (13.46 +/- 1.