[Oxidative stress, rRNA genes, and antioxidant enzymes in pathogenesis of schizophrenia and autism: modeling and clinical advices].

Ribosomal genes (RG), or genes for rRNA, are represented by multiple tandem repeats in eukaryotic genomes, and just a part of them is transcriptionally active. The quantity of active copies is a stable genome feature which determines the cell's capability for rapid synthesis of proteins, necessary to cope with stress conditions. Low number of active RG copies leads to reduced stress resistance and elevated risk of multifactorial disorders (MFD).

[Children mental health and influencing factors].

According to Russian and world publications, there is a growing prevalence of mental disorders among children and adolescences with the domination of mental retardation and nonpsychotic mental disorders. In this review, several main causes of growing prevalence of mental and behavioral disorders in these populations are specified.

[Efficacy of pantogam in the treatment of hyperkinetic disorders in children].

We have analyzed the efficacy of nootropic drug pantogam in the treatment of hyperkinetic disorders in children aged 6-12 years. The results of the randomized placebo-controlled trial demonstrated the decrease of major symptoms of hyperkinetic disorders (inattention, hyperactivity, impulsivity), comorbid mental and behavior disorders, the improvement of cognitive functions in the group of children treated with pantogam during 6 weeks and the absence of significant changes in the placebo group. It has been concluded that pantogam is effective in the treatment of hyperkinetic disorders in children.

[Pharmacogenetics of community-acquired pneumonia].

The rate of acetylation of xenobiotics affects the course and prognosis of infectious diseases. The efficacy of antibiotic therapy of community-acquired pneumonia in RA-patients is lower than that in LA-ones. In order to ensure the best antimicrobial effect on the onset of the disease it is required to use regimens with the maximum permissible dose of antibacterial drugs in the regions where the rapid type prevails.

[Elaboration of a patient management protocol for Hyperkinetic disorders in children and adolescents].

A paper reviews principles of elaboration of a patient management protocol for patients with hyperkinetic disorders. The data on clinical presentations, etiology and pathogenesis as well as approaches to diagnostics and systematics of this disorder, including questionable and unsolved aspects of the problem, which underlie these principles are discussed. The author emphasizes the necessity of further studies on clarifying and justification of some issues relating to diagnostics and treatment of hyperkinetic disorders.