[Current possibilities of the diagnosis and surgical treatment of acute thrombophlebitis and severe forms of varicose disease].

The data on examination and surgical treatment of 35 patients, suffering severe forms of varicose disease in stage of trophic disorders occurrence and with an acute thrombophlebitis are adduced. The concept of an active surgical help, including thromboembolic complications prophylaxis, depending on thrombophlebitis localization, correction of the venous hemodynamics disorders and the staged closure of trophic ulcer is substantiated. Introduction of the proposed tactics had permitted to achieve satisfactory outcomes, including the trophic ulcer healing and the trophic disorders regression in all the patients operated on.

[Effect of ethanol, diazepam, and reserpine on the activity of angiotensin-converting enzyme and carboxypeptidase in normal state and during stress].

There was discovered a resemblance in the influence of some pharmacological agents such as ethanol, diazepam and rezerpine on the activity of enzymes of metabolism of biological active peptides in the blood under emotional stress. It was determined that the character of the influence depends on the emotional status of animals. The possibility of drawing both angiotensin converting enzyme and carboxypeptidase N in the stress-protection action of the ethanol, diazepam and rezerpine is discussed.

[Effect of captopril on angiotensin-converting enzyme activity and animal behavior in the "open field" test].

Captopril was investigated for its effects on the activity of angiotensin-converting enzyme in the rat blood serum, pituitary, hypothalamus, and striatum, as well as for those on the animals, behavior in the open-field test. During its single administration the agent was found to lower the activity of angiotensin-converting enzyme in all the examined brain regions and serum. During chronic administration captopril decreased the mobility of the animals in the open-field test, diminished, the activity of the enzyme in the hypothalamus and striatum and enhanced it in the pituitary and serum.

[Effect of glucocorticoids on activity of soluble and membrane-bound forms of carboxypeptidase H in vivo].

Inhibition of soluble and membrane-bound carboxypeptidase H in rat hypothalamus, striatum and pituitary gland by hydrocortisone and dexamethasone treatment in vivo has been established. Differences in the dynamics of change in the activity were determined by the action of hydrocortisone and dexamethasone. Differences of the dynamics of change in soluble and membrane-bound carboxypeptidase H activity were also observed.