[Alveolar bone and dental arch defects fulfillment in cleft lip and palate patients].

Nine cleft lip and palate patients aged 17-32 years were included in the study, all having significant maxilla alveolar bone defects. Oral rehabilitation was possible by means of bone augmentation with iliac crest graft, soft tissue plasty and subsequent dental implantation (3 to 6 months after first-step procedures).

[Bone regenerate structural organization in experimentally reproduced defects of mandible branches under xenogenic stromal cells influence].

In experiment on rabbits by histomorphometric method it was shown that after the use during 4 months of titanium plate with the culture of marrow mesenchymal stromal cells there happened full infill of mandible defect by lamellar bone tissue. In control group (titanium plate with inactivated culture of cells) the defect was replaced by regenerate, the most part of it was rough fibrous connective tissue. In experimental group in the central parts of the defect regenerate were characterized by bigger weight of lamellar bone matrix if compared with the peripheral parts of the defect that testified to higher level of its differentiation.

[Evaluation of reparative regeneration of the jaw bone by microfocus roentgenography in an experiment].

In experiment on 16 grown-up chinchilla rabbits the dynamic of reparative regeneration was evaluated by digital microfocal rontgenography in the terms of 1, 2 and 4 months. Bone defect of the 8capital CHE, Cyrillic8 mm size in the region of mandible angle was caused by surgical laser Smart 2940 D+ on the right side and by physiodespenser Surgec XT on the left side. Surgical laser use let to reduce intact mother bone traumatisation and to improve remote results of bone tissue regeneration.

[Bone defects of ramus mandibulae healing in rabbits under bioengineering constructions from titanium and gold alloy with xenogenic mesenchymal stem cells].

Aim of the study was substantiation in experiments on rabbit ramus mandibulae of the method of mesenchymal stem cells (MSC) on the carrier from titanium and gold alloy for reparative osteogenesis enforcement. There was shown stimulating action of the MSC implantation in the bone wound upon reparative osteogenesis at the terms from 1 to 4 months. It was concluded that implants from titanium and gold alloy may be used as carrier for MSC for bone tissue reparative regeneration stimulation.

Effect of hydroxyapatite as a component of biostable composites on population and proliferation of mesenchymal stem cells.

Three groups of biostable composite materials were studied. The initial binder polymers (polymethylmethacrylate, polyamide-12, superhigh-molecular-weight polyethylene) and hydroxyapatite-containing composites on the basis of these polymers were tested. Biostable polymers, including those containing hydroxyapatite, were nontoxic for fibroblasts and mesenchymal stem cells: the adhesion parameters for these cells were maximum for polyamide-12 and superhigh-molecular-weight polyethylene and did not depend on the presence of hydroxyapatite.