The Effect of Cervical Conization on Women's' Sexual Function and Psychological Health, A Prospective Observational Study.

Background: Diagnosis of cervical dysplasia and subsequent conization of the uterine cervix might affect women's' sexual health.

Aim: To assess the effect of cervical conization on women's sexual function and psychological wellbeing.

Methods: Patients undergoing conization of the cervix were assessed before, and 6 months after conization.

A look at emerging delivery systems for topical drug products.

The introduction of new topical drugs based on new chemical entities has become a rare event. Instead, pharmaceutical companies have been focused on reformulating existing drugs resulting in an ever-growing number of topical drug products for every approved drug substance. In light of this trend, soon reformulations may not be as rewarding to their sponsors as they are today unless they offer a substantial improvement over other formulations of the same drug substance and the same indication, namely improved efficacy over existing drugs, reduced side effects, unique drug combinations, or applicability for new indications.

[Exercises involving strength in a physical rehabilitation program for obese women].

A comparative evaluation was done of two different 6-week physical rehabilitation schemes for obese women (n = 18) aged 39-45 years. On the basis of the above evaluation it has been shown that the program with elements of training involving strength was associated with a significantly greater reduction in specific weight of the adipose tissue than with conventional content of training sessions. The main cause of a higher effect of such a scheme can be attributed to increase in resting metabolism.

[The toxicokinetics of low-solubility substances (exemplified by 2 boron compounds)].

Multichamber toxicokinetic model studies of the resorption, distribution and excretion properties of poorly soluble substances in subchronic action of suspensions administered intragastrically can be the first step in prognosing the toxicokinetic properties of the inhaled aerosols of the substances mostly discharged from the respiratory into the gastrointestinal tract (GIT). The generally accepted quantitative characteristics of the particles' deposition and translocation into GIT can provide a further application of the model for a mathematical description of a prolonged inhalational exposure to some substances. This technique was tested with the boron compounds characterized by low solubility and revealed a good correlation between the prognosed and actual deposits of the substance in the organ and excretions.