CLINICAL SIGNIFICANCE OF BRCA1 GENE SEQUENCING AND ITS PROMOTER METHYLATION TESTING IN THE SEARCH STRATEGY FOR THERAPEUTIC TARGETS IN BREAST CANCER TREATMENT.

Background: Currently, there is a great interest in the genetic testing of BRCA1 and BRCA2 due to the fact that for patients with breast cancer (BC) with pathogenic variants of these genes, the use of the PARP inhibitors could be also provided in addition to implemented treatment protocols. The aim of this study was to characterize the molecular genetic structure of the BRCA1 gene in BC patients without progenitor germline mutations taking into account the methylation state of the promoter region.

Materials And Methods: The study involved 210 patients with newly diagnosed BC.

Integrated primary care behavioural health in a regional network of FQHC agencies during COVID-19.

Objectives: (1) Examine the ability to sustain integrated primary care behavioural health (eg, colocation, communication and coordination) in 40 community health centres, during the COVID-19 pandemic and (2) review adaptations and challenges to provide integrated behavioural health via telehealth.

Methods And Analysis: This qualitative investigation assessed 55 behavioural health consultants (BHCs), via semistructured interviews, spanning 40 practice sites and 10 organisations, on their adjustment to telehealth delivery, modified practice workflows and challenges of maintaining integration while displaced by the pandemic. Assessment of the level of integrated care was also conducted with available semistructured tools.

Contribution of BRCA1 5382insC mutation to triplene-gative and luminal types of breast cancer in Ukraine.

Purpose: The gene BRCA1 plays a key role in DNA repair in breast and ovarian cell lines and this is considered one of target tumor suppressor genes in same line of cancers. The 5382insC mutation is among the most frequently detected in patients (Eastern Europe) with triple-negative breast cancer (TNBC). In Ukraine, there is not enough awareness of necessity to test patients with TNBC for BRCA1 mutations.

Investigation of the Possibility of Using Microspectrometers Based on CMOS Photodiode Arrays in Small-Sized Devices for Optical Diagnostics.

The article considers the potential applicability of C12880MA and C11708MA Hamamatsu microspectrometers, which are characterized by an extremely compact design, occupying a small volume of several cubic centimeters, in portable spectrometric equipment with spatial resolution for monitoring the optical properties of condensed scattering media. The development of methods for determining the reduced scattering and absorption spectral coefficients of radiation from various scattering materials and products allows us to speak about the possibility of real-time control of the volume concentration of optically active components included in them, for example, fat and water in dairy products. For this, it is necessary to provide sufficiently accurate spectra of diffusely reflected broadband light radiation at different distances between the points of radiation entrance and registration.

COVID-19 and mental health in America: Crisis and opportunity?

There is opportunity in every crisis. COVID-19 has presented an unprecedented crisis. What opportunity can be gleaned from it? Unlike crises in the more recent past, such as the bombing of the Twin Towers and Pentagon on 9/11, COVID-19 is an ongoing global pandemic, affecting nearly every person on the planet in some shape or form.