[Influence of maternal factor on motor behavior and lipid turnover in rats exposed to severe psychoemotional stress].

Adverse condition of rat development during the prenatal period (rearing by mother survived brain injury) or during the early post-natal period (cross fostering), causes impairment of motor behavior and a lipid turnover in adult rats. Such rats under severe stress showed decrease of adaptation (as expressed or low indexes of motor impellent behavior and lipid metabolism) in comparison with rats that were grown up by own mother. The psychoemotional stress caused the most expressed deficient behavior in males that were grown up by mothers with brain injury (decrease in serum level of HC and HDL and depressively - similar behavior).

[Hypolipidemic activity of trimethylglycine].

Hypolipidemic properties of a native trimethyl derivative of glycine, trimethylglycine (TMGl), were studied in hyperlipidemic rats and guinea pigs. The administration of TMGl to the hyperlipidemic rats and guinea pigs produced a pronounced hypolipidemic effect. A positive action of TMGl on the lipid profile of blood serum of the experimental animals was observed as manifested by a decrease in the level of cholesterol of low density lipoproteins (LDL) and an increase in the cholesterol level of high density lipoproteins (HDL).

[Disturbances in the function of cardiomyocyte ryanodine receptors of spontaneously hypertensive rats revealed by 4-chloro-m-cresol].

The rates of Ca2+ release from sarcoplasmic reticulum in response to the activation of ryanodine receptors by 4-chloro-m-cresol in cardiomyocytes of three rat lines: spontaneously hypertensive (SHR) and normotensive WKY, and Wistar rats during five weeks of their growth and development have been studied to reveal differences in the function of ryanodine receptors at different stages of hypertension. Whereas the efflux of Ca2+ from sarcoplasmic reticulum in Wistar and WKY rat cardiomyocytes decreased in response to 4-chloro-m-cresol, an abrupt rise in the rate of [Ca2+]i increase was observed in myocytes of spontaneously hypertensive rats after 17 days of development. A correlation between this phenomenon and the occurrence of genetic defect of ryanodine receptors in SHR seems improbable because we did not register any differences in the rates of Ca2+ release from sarcoplasmic reticulum by the action of 4-chloro-m-cresol in concentrations 0.

[Experience in treating chronic periodontal diseases with vilprafene (josamycin)].

Forty-two patients with chronic generalized periodontitis were treated. Thirty-five patients presented with exacerbation of the disease of second-third degree of severity, clinically manifesting with hyperemia, edema of the gingival mucosa with pyorrhea from the gingivodental pouches, and mobility of teeth of the second-third degree; exacerbation of the process with abscesses round 1-2 teeth was observed in 4 patients, abscesses in the periodontal bone in 2, and edematous hypertrophic gingivitis in 1 patient. All patients were treated with vilprafene.

[Effects of parathyroid hormone and parathyroid hypertensive factor on myocardial mechanical properties in normotensive rats].

After a 10-minute incubation, both the parathyroid hypertensive factor (PHF) and parathyroid hormone (PTH) reduced myocardial contractility and accelerated myocardial relaxation. Effects of the PTH and PHF on myocardial inotropic characteristics were of opposite directions.