Publications by authors named "N N Jimenez-Vargas"
Article Synopsis
- This study examines the tolerance development to opioids, focusing on fentanyl and a new μ-opioid receptor agonist, NFEPP, which is activated in acidic environments typical of inflammation.
- Researchers conducted tests on mice with colitis to assess the analgesic effects and tolerance of both opioids over five days.
- Results showed that while fentanyl led to tolerance and cross-tolerance, NFEPP did not, suggesting it could offer pain relief without the risk of escalating dosages and increased side effects.
Background & Aims: Abdominal pain is a major symptom of diseases that are associated with microbial dysbiosis, including irritable bowel syndrome and inflammatory bowel disease. Germ-free mice are more prone to abdominal pain than conventionally housed mice, and reconstitution of the microbiota in germ-free mice reduces abdominal pain sensitivity. However, the mechanisms underlying microbial modulation of pain remain elusive.
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- Researchers are studying a special kind of pain medicine called NFEPP that works better in acidic areas of the body, which helps with painful conditions like colitis.
- In tests on mice, NFEPP provided pain relief during inflammation without causing harmful side effects that are often seen with regular pain medicines like fentanyl.
- This means that NFEPP could be a safer option for treating severe stomach pain during flare-ups of diseases like ulcerative colitis.
Background: Monosodium glutamate (MSG) has been identified as a trigger of abdominal pain in irritable bowel syndrome (IBS), but the mechanism is unknown. This study examined whether MSG causes visceral hypersensitivity using a water-avoidance stress (WAS) mouse model of visceral pain.
Methods: Mice were divided into four groups receiving treatment for 6 days: WAS + MSG gavage, WAS + saline gavage, sham-WAS + MSG gavage, and sham-WAS + saline gavage.
Gastrointestinal research in Latin America is hampered by a lack of financial support and by biases, affecting research advancement in the region and career development of Latin American scientists. Engagement of the next generation of leaders and established scientists is, therefore, essential to avoid perpetuation of the existing inequalities.
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