[Effect of phenothiazines on the viscosity and electrical stability of model phospholipid membranes].

The effect of five phenothiazine derivatives on the viscosity of model phospholipid membranes (by eximerization of pyrene) and on their electrical stability has been studied All the phenothiazines tested (chlorpromazine, propazine, triftazin and nonachlazine), except for chloracyzine, considerably increase the viscosity of phospholipid liposome bilayer at a concentration of 10(-5)-10(-4) M. Phenothiazines have been also shown to decrease liposome break-down potential even at a concentration of 10(-7) M. No correlation between the magnitude of break-down potential and changes in liposome membrane viscosity has been revealed.

[Biochemical mechanisms of the effect of low molecular weight organochlorine aliphatic compounds on humans and animals (review)].

Data on the effects of 1,1,1-trichlorethane and tetrachlorethylene on human and animal organisms are reviewed. These compounds are used in industry and in homeservice. The review deals with some aspects of the action of these organic solvents at the subcellular level.