[Features of rat cells karyotypic abnormalities in rat cells in their transformation in vitro].

Neoplastic transformation of cells is characterized by karyotypic abnormalities involving aneuploidy, quantitative changes, as well as multiple clonal rearrangements of the number and structure of chromosomes. It is probable that chromosomes are one of the mechanisms of cells immortalization and transformation. Despite many years of study of chromosomal rearrangements, data on primary chromosomal rearrangements in early stages of transformation is still insufficient.

[Intraocular hydrodynamics failure as a part of age cataract etiopathogenesis].

59 (105 eyes) patients with initial, premature and mature cataract are studied. Besides 14 patients (19 eyes) 1-2 years after cataract phacoemulsification with IOL implantation were examined. All patients underwent routine ophthalmological examination and tonography.

[Characteristics of the spontaneously transformed human endothelial cell line ECV304. I. Multiple chromosomal rearrangements in endothelial cells ECV304].

Karyotype of endothelial line ECV304 cells obtained from human umbilicus vein endothelial cells was studied using G-banding chromosome staining. It has been revealed that the cells have a polyploidy karyotype with 96-112 chromosomes and multiple numerical and structural clonal rearrangements. Almost all the chromosomes of the karyotype are involved in structural rearrangements.

[Chromosomal rearrangements and their effects in spontaneous immortalization and transformation of rat embryo cells in vitro].

G-banding analysis of LRec-1 and LRec-3, spontaneously immortalized cell lines from rat embryo fibroblast, revealed diploid karyotypes with specific clonal structural rearrangements of chromosomes 7 and 19 - del(7)(q11.2q22.1), t(7;19)(q11.