[Ability of energy metabolism of cells to activate repair of its genetic material after radiation damage].

A new hypothesis on a mechanism of action of the radioprotective and medical preparations involving the activation of oxidative phosphorylation and biogenesis of mitochondria which provides the increase of dimension and rapidity of the cellular reparation has been suggested. A previously unknown property of mitochondrions to determine a cellular homeostasis has been found. An activation of oxidative phosphorylation of mitochondria is a way of cellular protection against extreme conditions (namely, against radiation exposure and tumor formation).

[Genetic analysis of mitochondrial rho-mutability in Saccharomyces. IV. Relation between spontaneous rho-mutability and mitotic stability in disomic Saccharomyces cerevisiae].

In the yeast Saccharomyces cerevisiae the disomy for chromosome XIV resembles the previously described disomy for chromosome IV in that it leads to a significant decrease in spontaneous rho- mutability. The nuclear srm1 mutation, reducing spontaneous rho- mutability, diminishes significantly the mitotic disome stability. So, the mechanisms of spontaneous rho- mutagenesis and mitotic disome stability seem to compete for the function affected by the srm1 mutation.

[Effect of temperature on the occurrence and repair of radiaiton-induced damage to V. faba and Chinese hamster cells].

Keeping of irradiated cells at the temperature differing from the optimal one affects differently the stages of the cellular cycle and survival rate revealing the protection in G2 at 4 degrees C and increasing the number of cells with aberrations at the expense of interchromosome chromide translocations. Caffein decreased the survival rate of cells kept in suspension at 4 degrees C.