Pharmacokinetics, pharmacodynamics, safety, and immunogenicity of HLX14 versus reference denosumab in healthy males: A randomized phase I study.

Denosumab is a human IgG2 monoclonal antibody against receptor activator of nuclear factor kappa-B ligand (RANKL) for the treatment of osteoporosis and bone loss. HLX14 is a proposed biosimilar of denosumab. This randomized, parallel-group, two-part, phase I study aimed to compare the pharmacokinetics, pharmacodynamics, safety, and immunogenicity of HLX14 with reference denosumab in Chinese healthy adult male participants.

Unlocking the Ultrafast Deposition Kinetics within Bi-Tailored Core-Shell Structured Carbon Nanofibers for Highly Efficient and Ultrastable Sodium Metal Batteries.

Sodium metal anodes (SMA), featuring high energy content, low electrochemical potential and easy availability, are a compelling option for sustainable energy storage. However, notorious sodium dendrite and unstable solid-electrolyte interface (SEI) have largely retarded their widespread implantation. Herein, porous amorphous carbon nanofiber embedded with Bi nanoparticles in nanopores (Bi@NC) was rationally designed as a 3D host for SMA.

Specialized post-arterial capillaries facilitate adult bone remodelling.

The vasculature of the skeletal system is crucial for bone formation, homoeostasis and fracture repair, yet the diversity and specialization of bone-associated vessels remain poorly understood. Here we identify a specialized type of post-arterial capillary, termed type R, involved in bone remodelling. Type R capillaries emerge during adolescence around trabecular bone, possess a distinct morphology and molecular profile, and are associated with osteoprogenitors and bone-resorbing osteoclasts.