[Effect of ethanol on the enkephalinergic opioid system of the rat brain].

The effects of ethanol were examined on the main parameters of rat brain enkephalinergic neurotransmission, e.g., enkephalinase A activity, enkephalin content and specific binding of 3H-morphine and 3H-(D-Ala2, D-Leu5)-enkephalin.

[Interaction of D-Ala2-[Tyr-3,5-3H]enkephalin(5-D-Leu) with opiate receptors of rat brain].

Some kinetic features of D-Ala2-[Tyr-3.5-3H]enkephalin (5-D-Leu) binding to opiate receptors of rat brain were studied. It was shown that the Leu-enkephalin D analog interacts with the high and low affinity binding sites of opiate receptors, the equilibrium constants being equal to 0.

[Role of age-related serum factors in the mechanism of interferon production].

The activity (free and total) of cathepsin D and acid phosphatase was studied in cells of peritoneal exudate of mice of different ages in the process of interferon production in the presence of sera from newborn and adult animals. Cathepsin D release in newborn mice upon interferon induction is actively stimulated by serum factors of newborn animals altering lysosome permeability selectively for this enzyme alone. Another lysosomal enzyme, acid phosphatase, was more strongly bound to the structures and showed no such features.