Cytokine Profile in Lung Cancer Patients: Anti-Tumor and Oncogenic Cytokines.

Lung cancer is currently the second leading cause of cancer death worldwide. In recent years, checkpoint inhibitor immunotherapy (ICI) has emerged as a new treatment. A better understanding of the tumor microenvironment (TMJ) or the immune system surrounding the tumor is needed.

Clinical validation of the novel CLIA-CA-62 assay efficacy for early-stage breast cancer detection.

Background: Without organized screening programs up to 60-70% of breast cancers are diagnosed at advanced stages that have significantly lower five-year survival rate and poorer outcomes, which is a serious global public health problem. The purpose of the blind clinical study was the assessment of the novel diagnostic chemiluminescent CLIA-CA-62 assay for early-stage breast cancer detection.

Methods: Blind serum samples of 196 BC patients with known TNM staging, 85% with DCIS, Stage I & IIA, and 73 healthy control subjects were analyzed with the CLIA-CA-62 and CA 15-3 ELISA assays.

[Perioperative risk factors of bleeding in extensive liver resections].

Objective: To study the risk factors of severe blood loss in extensive liver resections, consequences of hemorrhagic problems and their correction.

Material And Methods: The study included 374 patients. Group 1 comprised 282 patients (118 men and 164 women aged 54.

[Blood-saving technologies in extensive liver resections].

The researches devoted to blood-saving technologies in extensive liver resections are analyzed in the manuscript. Resection of three and more liver segments is effective method of surgical treatment of various focal liver lesions. Surgical (anatomical resection with hilar glissonean access, Pringle maneuver, modern technical equipment, etc.

Short-term results of pancreatoduodenectomy in patients over 70 years old.

Objective: To analyze the immediate results of PDE in patients younger and older 70 years.

Material And Methods: The study included patients who underwent PDE for various indications from March 2010 to February 2019. All patients are divided into 2 groups: <70 years old and ≥70 years old.