Publications by authors named "N Mukhamedova"
Article Synopsis
- Oxy210, an oxysterol-based drug, shows promise in treating atherosclerosis and NASH due to its antifibrotic and anti-inflammatory effects.
- In studies with a special mouse model and cell types, Oxy210 significantly reduced atherosclerotic lesions and inflammatory markers related to atherosclerosis.
- The results indicate that Oxy210 may be an effective drug candidate for tackling both NASH and atherosclerosis, along with related chronic inflammation.
Extracellular vesicles (EVs) serve as pivotal mediators of intercellular communication in both health and disease, delivering biologically active molecules from vesicle-producing cells to recipient cells. In the context of HIV infection, EVs have been shown to carry the viral protein Nef, a key pathogenic factor associated with HIV-related co-morbidities. Despite this recognition, the specific localisation of Nef within the vesicles has remained elusive.
View Article and Find Full Text PDFWhen implanting a posterior chamber phakic intraocular lens (pIOL), it is crucial to maintain a safe distance. The patient was a 29-year-old man with high-degree bilateral myopia. In February 2021, posterior chamber acrylic pIOLs (Eyecryl Phakic TORIC; Biotech Vision Care, Gujarat, India) were implanted in both his eyes.
View Article and Find Full Text PDFArticle Synopsis
- - The study explores "trained immunity" in HIV-infected individuals, suggesting that hyperreactive myeloid cells contribute to chronic inflammation even under anti-retroviral treatment.
- - Human monocyte-derived macrophages treated with HIV-1 protein Nef release more pro-inflammatory cytokines after stimulation, due to chromatin changes affecting inflammation and cholesterol metabolism.
- - Both bone-marrow-derived macrophages from exNef-treated mice and those transplanted with exNef bone marrow show increased production of tumor necrosis factor α (TNF-α), which reflects the persistent inflammatory response linked to HIV infection.
In this research, samples of an alloy with a bimodal structure were studied on the basis of a previously developed technology for obtaining hydrogen storage materials based on the Ti-Al-Nb system. The results of SPS of mechanically activated powder mixtures of the Ti-Al-Nb system at a temperature of 1300 °C make it possible to obtain an alloy with a predominantly bimodal structure. However, an insignificant presence of TiAl, AlNb phases, and unreacted niobium is still observed in the structure.
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