Publications by authors named "N Mukerjee"
Article Synopsis
- Stem cell therapy is an exciting area of medicine that could change how we treat cancer and brain diseases.
- Scientists are looking at special cells called Mesenchymal Stem Cells (MSCs), which can help either grow or fight tumors, and how they release tiny particles called exosomes that affect cancer growth.
- Genetic changes to stem cells might help deliver medicine directly to tumors, making this therapy promising for healing and managing diseases in the future.
H5N1, a highly pathogenic avian influenza virus, poses an ongoing and significant threat to global public health, primarily due to its potential to cause severe respiratory illness and high mortality rates in humans. Despite extensive efforts in vaccination and antiviral therapy, H5N1 continues to exhibit high mutation rates, resulting in recurrent outbreaks and the emergence of drug-resistant strains. Traditional antiviral therapies, such as neuraminidase inhibitors and M2 ion channel blockers, have demonstrated limited efficacy, necessitating the exploration of innovative therapeutic strategies.
View Article and Find Full Text PDFThe increase in diseases caused by RNA viruses, such as influenza, severe acute respiratory syndrome-coronavirus (SARS-CoV), Middle East respiratory syndrome (MERS), and Ebola, presents a growing global health challenge as well as the threat of zoonosis. Traditional antiviral treatments are often undermined by fast-mutating viruses, drug resistance, and newly emerging pathogens. Here, we explore proteolysis-targeting chimeras (PROTACs), a novel protein degradation machinery that has the potential to reshape the way in which RNA viral infections can be managed.
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- A new study highlights the promising potential of 3,6-diaminoacridine-9-carbonitrile (DAC) in treating lung cancer, particularly through its derivative CTX-1, which shows stronger binding affinity to the EGFR-TKD protein than the standard drug Erlotinib.
- Molecular dynamics simulations confirm CTX-1's stability and effectiveness, with tests indicating it significantly outperforms Erlotinib against various lung cancer cell lines in inhibiting cancer cell growth and inducing cell death.
- The findings suggest that CTX-1 could represent a major advancement in lung cancer therapies, shifting current treatment paradigms and opening new possibilities for combating the disease.
Exosomes play a crucial role in intercellular communication and have emerged as significant vehicles for transporting disease-specific biomarkers. This feature provides profound insights into the progression of diseases and the responses of patients to treatments. For example, in leukemia, exosomes convey critical information through the carriage of specific proteins and nucleic acids.
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