Publications by authors named "N Mourdi"
Article Synopsis
- The study reports pediatric cases of serious respiratory adverse drug reactions (ADRs) linked to oral mucolytic drugs, leading to their market withdrawal for infants in France and Italy.
- The analysis, conducted from 1989 to 2008, involved voluntarily reported cases of children experiencing paradoxical respiratory issues after using these drugs.
- Findings revealed that the majority of affected infants, mostly under 2 years old, required hospitalization for conditions like increased mucus production and worsening respiratory distress, suggesting significant safety concerns with these medications.
Article Synopsis
- - The study aimed to identify how often suboptimal care and medical errors occur in children who died from severe bacterial infections, hoping to improve healthcare quality.
- - Conducted in two districts in France between 2000-2006, the analysis of 21 cases revealed that 76% of initial medical management was deemed suboptimal, with agreement between experts being high (kappa of 0.73).
- - Key errors included delays in both parents and physicians seeking or providing treatment, inadequate fluid resuscitation, and overall underestimating the severity of the illness, highlighting significant areas for improvement in pediatric care.
Background: Acetylcysteine and carbocysteine are the most commonly prescribed mucolytic drugs in many European countries. To our knowledge, no systematic review has been published on their efficacy and safety for acute upper and lower respiratory tract infections (ARTIs) in children without chronic broncho-pulmonary disease.
Objectives: The objective was to assess the efficacy and safety and to establish a benefit-risk ratio of acetylcysteine and carbocysteine as symptomatic treatments for ARTIs in children without chronic broncho-pulmonary disease.