Publications by authors named "N Mossaheb"
Article Synopsis
- Individuals at ultra-high risk (UHR) for psychosis with persistent attenuated psychotic symptoms (APS) show worse clinical and functional outcomes compared to those who remit, closely resembling individuals who transition to psychosis.
- After an initial period, the symptom and functioning trajectories for those with persistent APS diverge quickly from those who remit.
- Prediction of non-remission improves significantly with longitudinal data (6-month follow-up) rather than relying on baseline data alone, indicating the need for consistent monitoring and intervention for UHR individuals with persistent APS.
Background: The involvement and engagement of people with lived experience is considered increasingly important in health research. A growing corpus of literature on the involvement of people with lived experience of mental health conditions, including people at psychosis high risk states, can be found. This study aims to explore the subjective experience of researchers and co-researchers with lived experience of psychosis high risk states who were involved in a participatory research project.
View Article and Find Full Text PDFThe concept of ultra-high risk for psychosis (UHR) has been at the forefront of psychiatric research for several decades, with the ultimate goal of preventing the onset of psychotic disorder in high-risk individuals. Orygen (Melbourne, Australia) has led a range of observational and intervention studies in this clinical population. These datasets have now been integrated into the UHR 1000+ cohort, consisting of a sample of 1,245 UHR individuals with a follow-up period ranging from 1 to 16.
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- - Psychosis risk prediction in psychiatry is challenging, and a study aimed to evaluate whether a specific proteomic model could accurately predict the transition to psychosis in individuals at clinical high risk, using plasma samples from three cohorts totaling 754 participants.
- - The study found that only 20.4% of participants developed psychosis over about 4.4 years, and the prediction model had poor accuracy (C-statistic: 0.51), suggesting that the proteomic factors didn't reliably predict outcomes.
- - Some proteins, like Complement C8B and LRG1, showed weak associations with psychosis transition but did not reach significant levels when correcting for multiple comparisons, indicating that previous claims based on small sample sizes should
A 28-year-old man was admitted to our psychiatric ward with severe obsessive-compulsive disorder (OCD) and comorbid depression. At intake, obsessive-compulsive symptoms were present most time of the day and were related to an intense fear of causing interpersonal misunderstandings. Various treatment attempts, including cognitive-behavioural therapy (CBT) with exposure and response prevention (ERP), selective serotonin reuptake inhibitors, clomipramine, and add-on antipsychotics were either ineffective and/or were not tolerated, and the patient's condition worsened progressively.
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