Publications by authors named "N Morgenthaler"
Article Synopsis
- Severe COVID-19 patients exhibit a dysfunctional immune response characterized by high levels of SARS-CoV-2 specific IgG antibodies that can lead to harmful effects rather than protection.
- The study identifies a significant activation of FcγRIIIA/CD16A in severely impacted patients, which is linked to the presence of soluble circulating IgG immune complexes (sICs) found in about 80% of these cases.
- The early formation of sICs before a specific immune response may be causing ongoing immunopathology, suggesting potential new intervention strategies to help those at risk of critical COVID-19 progression.
Background: Cardiac troponin (cTn) can be elevated in many patients presenting to the emergency department (ED) with chest pain but without a diagnosis of acute coronary syndrome (ACS). We compared the prognostic significance of cTn in these different populations.
Methods: We retrospectively analyzed the CHOPIN study, which enrolled patients who presented to the ED with chest pain.
Purpose: The aim of this study was to analyse the course of adrenomedullin (ADM) and endothelin-1 (ET-1) levels in patients with vasodilatory shock after cardiac surgery and to explore differences compared to patients after uncomplicated coronary artery bypass graft (CABG) surgery. ADM and ET-1 are involved in the vasomotor response during vasodilatory shock.
Materials And Methods: We included 32 patients with vasodilatory shock (study group) and 10 patients after uncomplicated CABG surgery (control group).
Background: The observed incidence of type 2 myocardial infarction (T2MI) is expected to increase with the implementation of increasingly sensitive cTn assays. However, it remains to be determined how to diagnose, risk-stratify, and treat patients with T2MI. We aimed to discriminate and risk-stratify T2MI using biomarkers.
View Article and Find Full Text PDFVasopressin (AVP) plays a major role in the regulation of water and sodium homeostasis by its antidiuretic action on the kidney, mediated by V2 receptors. AVP secretion is stimulated by a rise in plasma osmolality, a decline in blood volume or stress. V1a receptors are expressed in vascular smooth muscle cells, but the role of vasopressin in blood pressure regulation is still a matter of debate.
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