Publications by authors named "N Moorthy"
Article Synopsis
- Nearly 60,000 people in India die from snakebites each year, mainly in rural and tribal areas, prompting a study on snakebite epidemiology and treatment in Tamil Nadu.
- A cross-sectional survey revealed that snakebite incidence and mortality rates were similar in two studied regions, with high reliance on traditional healers for initial treatment, particularly in Jawadhu Hills.
- Major challenges include the use of dangerous first aid practices, poor communication between traditional healers and the healthcare system, and insufficient transportation options to health facilities, necessitating community awareness and better public transport solutions.
Article Synopsis
- Intercoronary communication (ICC) is a rare coronary artery anomaly that occurs in only 0.002% of patients undergoing angiography, highlighting the need for clinical awareness.
- A case study details a 56-year-old woman who experienced chest pain and was diagnosed with acute coronary syndrome; angiography revealed a significant stenosis and the existence of ICC, which connected two coronary arteries.
- The study concludes that it's important to differentiate ICC from collaterals, as they have distinct anatomical characteristics and flow patterns, with collaterals usually forming due to obstructive disease.
The transformer mineral oil is generally hydrocarbon-based and is not environmentally friendly, so it holds a significant share in environmental pollution. As an alternative to conventional transformer oil, plant-based insulation oil has been investigated globally in the past few decades. Even though vegetable oils are considered an environmentally viable alternative to mineral oil, the extensive utilization of vegetable oils could create a threat to Indian food security.
View Article and Find Full Text PDFContext: Multiwalled carbon nanotubes (MWCNTs) functionalized with lysine via 1,3-dipolar cycloaddition and conjugated to galactose or mannose are potential nanocarriers that can effectively bind to the lectin receptor in MDA-MB-231 or MCF-7 breast cancer cells. In this work, a method based on molecular dynamics (MD) simulation was used to predict the interaction of these functionalized MWCNTs with doxorubicin and obtain structural evidence that allows a better understanding of the drug loading and release process. The MD simulations showed that while doxorubicin only interacted with pristine MWCNTs through π-π stacking interactions, functionalized MWCNTs were also able to establish hydrogen bonds, suggesting that the functionalized groups improve doxorubicin loading.
View Article and Find Full Text PDFMulti-walled Carbon Nanotubes (MWCNTs) are inert structures with high aspect ratios that are widely used as vehicles for targeted drug delivery in cancer and many other diseases. They are largely non-toxic in nature however, when cells are exposed to these nanotubes for prolonged durations or at high concentrations, they show certain adverse effects. These include cytotoxicity, inflammation, generation of oxidative stress, and genotoxicity among others.
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