Publications by authors named "N Mokhtar"
: Diabetic ketoacidosis (DKA) is a critical complication of diabetes mellitus, posing significant health. While global studies have indicated a concerning lack of awareness regarding DKA among patients with diabetes, research specific to the northern area of Saudi Arabia remains limited. This study aims to explore the level of knowledge and awareness of DKA among patients with diabetes residing in the local region.
View Article and Find Full Text PDFBreast cancer (BC) is the most frequently diagnosed malignancy among women. It is characterized by a high level of heterogeneity that emerges from the interaction of several cellular and soluble components in the tumor microenvironment (TME), such as cytokines, tumor cells and tumor-associated immune cells. Tumor necrosis factor (TNF) receptor 2 (TNFR2) appears to play a significant role in microenvironmental regulation, tumor progression, immune evasion, drug resistance, and metastasis of many types of cancer, including BC.
View Article and Find Full Text PDFMetastatic breast cancer (MBC) is an advanced-stage breast cancer associated with more than 90 % of cancer-related deaths. Immunosuppressive properties of tolerogenic dendritic cells (tolDCs) in tumour immune microenvironment (TIME) may be a risk factor for the rapid progression to MBC. However, the exact connections between the two are unknown.
View Article and Find Full Text PDF: Patients with endometriosis still respond poorly to progestins due to progesterone resistance associated with microRNAs (miRNAs). The aim of this study was to investigate the expression of selected miRNAs, estrogen receptor (ER)α, ERβ, progesterone receptor (PR)-A and PR-B and to determine the target genes of upregulated miRNAs in endometriosis. : In this study, 18 controls, 18 eutopic and 18 ectopic samples were analysed.
View Article and Find Full Text PDFArticle Synopsis
- Lithium is crucial for treating psychiatric disorders but has a narrow therapeutic index, requiring careful monitoring.
- A case study reveals a 50-year-old man with bipolar disorder who developed chronic lithium toxicity and neuroleptic malignant syndrome (NMS) after dehydration from a viral illness, complicating his treatment.
- Recovery involved fluid therapy and supportive care, leading to a successful discharge with a lower potency medication and gradual dose adjustments.