Publications by authors named "N Mohd Yatim"
Maturation of conventional dendritic cells (cDCs) is crucial for maintaining tolerogenic safeguards against auto-immunity and for promoting immunogenic responses to pathogens and cancer. The subcellular mechanism for cDC maturation remains poorly defined. We show that cDCs mature by leveraging an internal reservoir of cholesterol (harnessed from extracellular cell debris and generated by de novo synthesis) to assemble lipid nanodomains on cell surfaces of maturing cDCs, enhance expression of maturation markers and stabilize immune receptor signaling.
View Article and Find Full Text PDFThis research focuses on investigating the buckling strength of thin-walled composite structures featuring various shapes of holes, laminates, and composite materials. A parametric study is conducted to optimize and identify the most suitable combination of material and structural parameters, ensuring the resilience of structure under both mechanical and thermal loads. Initially, a numerical approach employing the finite element method is used to design the C-section thin-walled composite structure.
View Article and Find Full Text PDFArticle Synopsis
- Aging increases the risk of cancer by affecting how the immune system works, especially in lung tumors.
- Older immune cells lead to the buildup of certain cells that produce IL-1⍺, which makes cancer grow faster.
- By blocking IL-1R1 signaling early on, scientists found they could slow down cancer growth in the lungs, colon, and pancreas, and learned how aging is linked to worse cancer outcomes in humans.
Article Synopsis
- Sarcoidosis is a long-lasting immune disease without a clear cause, and researchers are trying to understand what triggers it and how it progresses.
- The article focuses on the role of myeloid cells in forming granulomas, which are clusters of immune cells associated with the disease, and discusses the concept of innate immune memory as a way to link past environmental exposures to the disease's symptoms.
- Finally, while corticosteroids are the main treatment, the authors suggest that their findings could lead to new treatment strategies for managing sarcoidosis.