Publications by authors named "N Modugno"
Article Synopsis
- The study investigates the lipid and metabolite profiles in Parkinson's disease (PD) patients to uncover new pathways and potential biomarkers for early detection and treatment.* -
- It highlights significant differences in lipid profiles among three groups (No L-Dopa, L-Dopa, and DBS) with findings that show increases in specific lipid species, particularly with deep brain stimulation (DBS) treatment.* -
- The research also reveals dysregulation in amino acid metabolism, especially L-glutamic acid, suggesting that DBS may positively influence glutamate levels, offering insights for future PD diagnosis and therapies.*
Article Synopsis
- Deep brain stimulation of the subthalamic nucleus (STN-DBS) offers motor benefits for Parkinson's disease patients, but its effectiveness on postural and gait issues remains uncertain.
- Physical therapy (PT) has shown effectiveness in improving mobility and stability in non-surgically treated Parkinson's patients, but its role after STN-DBS is less explored.
- A study involving 21 experts highlighted that while PT could enhance motor function and quality of life post-STN-DBS, there’s a preference for conventional therapies over massage or manual techniques.
Introduction: Gaucher's disease (GD) is caused by biallelic mutations in the GBA1 gene, leading to reduced glucocerebrosidase (GCase) activity and substrate (glucosylceramide and glucosylsphingosine, GlcSph) accumulation. GBA1 variant carriers are at risk of Parkinson's disease (PD), but only those with biallelic mutations cross the threshold of GCase reduction, leading to substrate accumulation and GD. The link between GBA1 mutations, GD and PD is not fully understood.
View Article and Find Full Text PDFNeurological disorders such as stroke, Parkinson's disease (PD), and severe traumatic brain injury (sTBI) are leading global causes of disability and mortality. This study aimed to assess the ability to walk of patients with sTBI, stroke, and PD, identifying the differences in dynamic postural stability, symmetry, and smoothness during various dynamic motor tasks. Sixty people with neurological disorders and 20 healthy participants were recruited.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated the effectiveness of Compassionate Mind Training (CMT) in improving quality of life and psychological well-being for people with Parkinson's disease (PD), particularly focusing on neuropsychiatric symptoms.
- Over a 6-week online intervention with 24 PD patients, significant improvements were observed in quality of life and reduction of perceived stigma, along with better stress regulation as indicated by increased heart rate variability (HRV).
- The findings suggest that CMT is a feasible approach for PD patients and that HRV could serve as a valuable physiomarker for assessing the impact of psychological interventions.