Publications by authors named "N Mladkova"
The epidemiology and potential pathogenic roles of human papillomavirus (HPV) and Merkel cell polyomavirus (MCV) in keratinocyte cancers (KCs) arising in people living with HIV (PLWH) compared with HIV-negative individuals are poorly understood. These issues were investigated by a case-control study in which the presence of MCV and HPV DNA was identified by polymerase chain reaction in microdissected formalin-fixed paraffin-embedded tissue from PLWH and HIV-negative individuals. The samples comprised 190 cutaneous and genital KCs/precancers (actinic keratoses, n = 43; cutaneous squamous cell carcinoma (cSCC) in situ, n = 24; basal cell carcinoma, n = 78; cSCC, n = 34; penile carcinoma in situ, n = 9; penile SCC, n = 2 from 104 individuals (PLWH, n = 51; HIV-negative, n = 53).
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- IgA nephropathy (IgAN) is a serious kidney disease linked to IgA buildup, and a large study identified 30 genetic risk factors associated with it.
- Fourteen new loci were discovered that suggest a connection between genetic influences and abnormal IgA levels.
- The research highlights inflammation-related pathways and potential drug targets, revealing that higher genetic risk scores are tied to earlier kidney failure.
Background: Immune checkpoint inhibitors (ICI) treatment in recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) offers new therapeutic venues. We have previously developed a predictive survival model in this patient population based on clinical parameters, and the purpose of this study was to expand the study cohort and internally validate the model.
Methods: A single institutional retrospective analysis of R/M HNSCC patients treated with ICI.
For the Love of Radiation Oncology: A Resident Trainee Perspective.
Int J Radiat Oncol Biol Phys
November 2021
The genomics and epigenetics of olfactory neuroblastoma: A systematic review.
Laryngoscope Investig Otolaryngol
August 2021
Article Synopsis
- Olfactory neuroblastoma (ONB), a rare cancer of the nasal cavity linked to the olfactory epithelium, was analyzed to understand its genomic, epigenetic, and cytogenetic profiles.
- A systematic review of 36 studies, including research articles and abstracts, was conducted to assess these genetic alterations in ONB, noting that while recurrent mutations are rare, certain gene alterations and chromosomal variations were observed.
- The study highlights the need for larger-scale genomic and epigenomic research to verify initial findings and to explore potential treatment options for this uncommon malignancy.