Publications by authors named "N Miyakawa"
Area TE is required for normal learning of visual categories based on perceptual similarity. To evaluate whether category learning changes neural activity in area TE, we trained two monkeys (both male) implanted with multielectrode arrays to categorize natural images of cats and dogs. Neural activity during a passive viewing task was compared pre- and post-training.
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- The study investigates HPH-15, a compound that activates AMPK, for its potential as a diabetes treatment, focusing on its ability to manage blood glucose levels and prevent complications.
- Researchers tested HPH-15's effects on glucose uptake and fat accumulation in different cell types and high-fat diet mice, comparing it to the established diabetes drug metformin.
- Results showed HPH-15 improved blood glucose levels and reduced fat accumulation more effectively than metformin, indicating it may be a promising therapeutic option for diabetes management.
Primates must adapt to changing environments by optimizing their behavior to make beneficial choices. At the core of adaptive behavior is the orbitofrontal cortex (OFC) of the brain, which updates choice value through direct experience or knowledge-based inference. Here, we identify distinct neural circuitry underlying these two separate abilities.
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- Visual object memory is crucial for various cognitive skills, and while the anterior temporal cortex's role has been studied in primates, the full picture including large-scale networks and neuronal dynamics is still unclear.
- Researchers found that the orbitofrontal node works closely with the anterior temporal node for object memory by using functional imaging and a short-term memory task in male macaques.
- Silencing the orbitofrontal node disrupted performance on memory tasks by affecting the anterior temporal cortex's function, demonstrating its significant role in enhancing memory signals while not altering perceptual processing.