[Effects of ultracaine on the local blood flow of the gum and on the development of cerebral seizures in experiment].

We have studied the effect of ultracaine DS forte on local blood flow of the rat gum as well as on the development of the convulsion activity of the brain at systemic injection. Experiments were carried out on 12 mongrel albino mail rats of 200-250 g weight. In the I group of animals under the light chloral hydrate anesthesia we studied the changes of local blood flow in the rat gum of lower jaw after ultracaine DS forte injection (right side) and the similar quantity of phisiological solution (left side).

[Changes in emotional state and learning process disorders in rats with experimental hepatic encephalopathy].

Animal models of liver failure are widely used for research of morphological and functional changes and pathogenetic mechanisms of hepatic encephalopathy. Changes in learning process and emotional state of rats, which were administered intraperitoneally (Phenobarbiton 40 mg/kg/day) for five days and then subcutaneously (Acetaminophen 1000 mg/kg) are described. Behaviour of rats was studied in the "open field".

[Local blood flow in the dorsal hippocampus and cerebellar cortex in progeny of iodine-deficient rats].

Experimental studies show depressive behavior in rats caused by hypothyroidism and antidepressant effect of thyroid hormones. The present study analyses changes in the hippocampal and cerebellar cortex local blood flow in the progeny of rats suffering from iodine deficiency before mating and during the whole period of gestation. The diet with very low iodine content results in a decrease of local blood flow in both brain structures, but the greatest changes were observed in hippocampus.

[Assessment of the lower threshold in autoregulation of the blood supply of the optic nerve disk].

Existence of the autoregulation phenomenon in the blood supply system of the optic nerve has been established in the 1990; however, some of its quantitative and qualitative characteristics still require clarification. The goal of the present work was assessment of the lower margin in autoregulation of the blood supply of the optic nerve in the rabbit in conditions of attenuated level of perfusion pressure. Total of six adult rabbits weighing 2.

[Altered ability to learn of rat offspring with iodine deficiency].

Experimental data demonstrate that hypothyroidism could result in depressive behavior and subsequently thyroid hormones could act as antidepressants. Postnatal changes in learning ability, memory and emotional status in posterity of rats, which have experienced different level of iodine deficiency before conception and during all gestation period were investigated in this study. Results obtained suggest that sudden iodine deprivation before and during gestation led to a significant neurological defect, which was represented by loss of ability to learn, one of the most important functions of brain in newborn and by evidence of depression.