Publications by authors named "N Mimica"

The lexical-semantic impairments at different levels of semantic processing are often observed in Mild cognitive impairment (MCI). To better understand the nature of the lexical-semantic impairment in MCI, this study included two experiments: a sensory rating task and a lexical decision task. Twenty individuals diagnosed with MCI were recruited as well as eighty healthy subjects to serve as a control group.

View Article and Find Full Text PDF

Advance care planning (ACP) is increasingly recognised in the global agenda for dementia care. The European Association for Palliative Care (EAPC) Taskforce on ACP in Dementia aimed to provide recommendations for policy initiatives and future research. We conducted a four-round Delphi study with a 33-country panel of 107 experts between September, 2021, and June, 2022, that was approved by the EAPC Board.

View Article and Find Full Text PDF
Article Synopsis
  • Dementia is a progressive syndrome primarily affecting the elderly, characterized by cognitive decline, particularly in memory and learning, with common types including Alzheimer's and vascular dementia.
  • The causes of dementia are complex and involve genetic and environmental factors, necessitating various medications to manage cognitive impairment and behavioral symptoms, but many patients experience significant variability in drug response and side effects.
  • Advances in pharmacogenomics offer potential for personalized treatment strategies, aiming to enhance the effectiveness and safety of dementia therapies, ultimately improving patients' quality of life.
View Article and Find Full Text PDF

Introduction: Existing advance care planning (ACP) definitional frameworks apply to individuals with decision-making capacity. We aimed to conceptualize ACP for dementia in terms of its definition and issues that deserve particular attention.

Methods: Delphi study with phases: (A) adaptation of a generic ACP framework by a task force of the European Association for Palliative Care (EAPC); (B) four online surveys by 107 experts from 33 countries, September 2021 to June 2022; (C) approval by the EAPC board.

View Article and Find Full Text PDF

Catechol--methyl transferase () gene variants are involved in different neuropsychiatric disorders and cognitive impairments, associated with altered dopamine function. This study investigated the genotypic and haplotypic association of rs4680 and rs4618 polymorphisms with the severity of cognitive and other clinical symptoms in 544 male and 385 female subjects with schizophrenia. rs4818 G carriers were more frequent in male patients with mild abstract thinking difficulties, compared to CC homozygotes or C allele carriers.

View Article and Find Full Text PDF