Publications by authors named "N Merz"
Protein S-palmitoylation is the process by which a palmitoyl fatty acid is attached to a cysteine residue of a protein via a thioester bond. A range of methodologies are available for the detection of protein S-palmitoylation. In this study, two methods for the S-palmitoylation of different proteins were compared after metabolic labeling of cells with 15-hexadecynoic acid (15-YNE) to ascertain their relative usefulness.
View Article and Find Full Text PDFBCR-ABL1 compound mutations can lead to resistance to ABL1 inhibitors in chronic myeloid leukemia (CML), which could be targeted by combining the ATP-site inhibitor ponatinib and the allosteric inhibitor asciminib. Here, we report the clinical validation of this approach in a CML patient, providing a basis for combination therapy to overcome such resistance.
View Article and Find Full Text PDFArticle Synopsis
- Fully automatic analysis of myocardial perfusion MRI helps in quick and objective reporting for patients suspected of ischemic heart disease. The study focuses on overcoming challenges related to varied training data and differences in MRI software and hardware.
- The research involved datasets from 150 subjects across three medical centers, utilizing a deep neural network (DNN) approach known as Data Adaptive Uncertainty-Guided Space-time (DAUGS) analysis for effective image segmentation.
- Results showed that DAUGS analysis performed similarly to established methods on internal data but significantly outperformed them on external datasets, indicating its robustness in diverse clinical settings.
The integrity of the colon and the development of colon cancer depend on the sphingolipid balance in colon epithelial cells. In this review, we summarize the current knowledge on how ceramides and their complex derivatives influence normal colon development and colon cancer development. Ceramides, glucosylceramides and sphingomyelin are essential membrane components and, due to their biophysical properties, can influence the activation of membrane proteins, affecting protein-protein interactions and downstream signalling pathways.
View Article and Find Full Text PDF