Publications by authors named "N Melling"
GALNT2, also known as polypeptide N-acetylgalactosaminyltransferase 2, is an enzyme that catalyzes the initial step of O-linked glycosylation, a crucial posttranslational modification that affects protein folding, stability, and function. Alterations in GALNT2 activity have been implicated in various diseases, such as cancer, metabolic disorders, and cardiovascular diseases, highlighting its importance in maintaining normal physiological functions. To investigate the impact of GalNT2 overexpression in vivo for the first time, we generated a conditional transgenic mouse line in which GalNT2 was expressed specifically in the pancreas.
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- Anterior gradient 2 (AGR2) is a key protein involved in various biological processes like embryonic development, tissue regeneration, and wound healing, with potential implications in cancer research.
- A comprehensive analysis of nearly 15,000 tumors and normal tissue samples revealed that AGR2 expression is present in a majority of tumor categories, particularly in tumors of the female genital tract and various adenocarcinomas.
- High levels of AGR2 are associated with poor clinical outcomes in several cancer types, suggesting its role as a potential biomarker for tumor aggressiveness and progression.
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- Researchers developed a novel risk score using molecular markers to predict survival in colorectal cancer patients, moving beyond traditional histopathological methods.
- The study analyzed 1791 patients using immunohistochemistry to measure the levels of H2BUB1, RBM3, and Ki-67, creating a scoring system based on these markers.
- Results indicated that the new risk score could independently predict patient survival, potentially offering a more personalized approach to treatment than classical methods.
Colorectal carcinomas are a rare but possible complication in an interposed colonic segment used for reconstruction after esophagectomy. We report the case of a patient who underwent colonic interposition surgery in childhood due to esophageal atresia and was diagnosed with colorectal adenocarcinoma of the interposed colon ~57 years later. The patient underwent gastric pull-up after thoraco-abdominal resection of the colonic interposition en bloc with the adjacent remaining esophagus.
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