Mixed methods evaluation of a digital resource to build students' skills in ASsessing cardiovascular risk, MOtivating change, and SUStaining a healthier lifestyle in themselves and others- ASMOSUS: a study protocol.

Background: Cardiovascular disease (CVD) is a prevalent cause of morbidity and mortality globally. Nurses and nursing students are in an optimum role to assess, manage and promote lifestyle changes associated with CVD risk. Patients and service users are more likely to adopt these changes if the person delivering the information embodies this lifestyle themselves.

Resilience Factors in Reentry From Juvenile Legal Facility Settings: A Scoping Review.

Internationally, there has been a decline in the use of juvenile legal facilities (Puzzanchera et al., 2022). Yet, it is well documented that the process of reentering the community following placement in these settings presents numerous challenges for young people.

Direct neutrophil and T cell contact with macrophages induces release of phagosomally processed PAMPs via eructophagy.

Macrophages play a pivotal role in clearing debris and microbes from the microenvironment via phagocytosis and orchestrating local inflammation. While mostly understood to be through the synthesis and secretion of soluble mediators such as cytokines and eicosanoids, it has been recently proposed that macrophages can release previously phagocytosed and processed PAMPs and DAMPs into the local microenvironment via a process termed eructophagy, and that these, in turn, can activate recently vicinal leukocytes. Additionally, it has been commonly observed that local macrophages physically interact with other leukocytes, such as neutrophils and T cells, recruited to sites of inflammation.

MAGE-A4 induces non-small cell lung cancer and tumor-promoting plasma cell accumulation.

Adaptive immunity is critical in eliminating tumors, but cancer-intrinsic factors can subvert this function. Melanoma antigen-A4 (MAGE-A4), a cancer-testis antigen, is expressed in solid tumors and correlates with poor survival, but its role in tumorigenesis and antitumor immunity remains unclear. We found that expression of MAGE-A4 was highly associated with the loss of , a tumor suppressor, in human non-small cell lung cancers (NSCLC).

Validated Integration of Tumor Deposits in N Staging for Prognostication in Colon Cancer.

Importance: Tumor deposits have prognostic value in colon cancer, but the current American Joint Committee on Cancer (AJCC) staging only considers them if there are no concurrent positive lymph nodes.

Objective: To devise a staging system for colon cancer by integrating counts of tumor deposits with positive lymph nodes while retaining the current AJCC staging framework.

Design, Setting, And Participants: This retrospective cohort study examines data from a large-volume, tertiary care center database (January 2010 through March 2023 with follow-up until December 2023) and the population-based National Cancer Database (January 2010 through December 2020 with follow-up until December 2021).