Publications by authors named "N McInnes"
Aims: When administered in early type 2 diabetes (T2DM), the strategy of 'induction' with short-term intensive insulin therapy (IIT) followed by 'maintenance' with metformin thereafter can yield outstanding glycaemic control, with some patients achieving A1c in the normal range of its assay. We thus sought to identify determinants of sustained normalisation of A1c in response to this treatment strategy.
Materials And Methods: In this study, adults with T2DM of mean duration 1.
Objectives: We report the findings of a novel enhanced syndromic surveillance that characterised influenza- and SARS-CoV-2-associated severe acute respiratory illness (SARI) in the 2021/2022 winter season.
Methods: Prospective cohort study of adults admitted to the Queen Elizabeth University Hospital, Glasgow, with a severe acute respiratory illness. Patient demographics, clinical history, admission details, and outcomes were recorded.
Objective: Alleviation of unrecognized glucotoxicity, with resultant recovery of β-cell function, could amplify the glucose-lowering effect of pharmacotherapy and contribute to the variable therapeutic response observed among patients with type 2 diabetes (T2D). However, clinical evidence supporting this concept is lacking. Short-term intensive insulin therapy (IIT) can ameliorate glucotoxicity and improve β-cell function in early T2D.
View Article and Find Full Text PDFHematologic Malignancies: Two Cases of a Rare Cause of Hypopituitarism.
JCEM Case Rep
September 2024
Article Synopsis
- Hematologic malignancies are rare but can cause sellar masses and hypopituitarism, as seen in two reported cases where patients developed hormone deficiencies.
- In one case, initial MRI did not reveal a mass, but follow-up imaging and a biopsy led to a diagnosis of intravascular lymphoma, and chemotherapy improved MRI findings.
- The second case involved a patient with chronic lymphocytic leukemia, whose sellar mass was confirmed through biopsy, and treatment with ibrutinib, acalabrutinib, and radiosurgery also resolved the sellar abnormalities.
Article Synopsis
- The study aimed to assess if a short-term intensive intervention combining dietary changes, exercise, coaching, metformin, and insulin could help achieve remission in type 2 diabetes patients.
- Participants were divided into an intervention group (16 weeks of intensive treatment) and a control group and were monitored for diabetes relapse for an additional year.
- Results showed that the intervention led to significant improvements in blood sugar levels and weight loss, but while it reduced the risk of relapse in the short term, it did not maintain remission rates over the long term.