Publications by authors named "N McGowan"

Article Synopsis
  • Borderline personality disorder (BPD) lacks widespread treatment options, and digital mental health interventions could help bridge this gap through effective behavior change strategies.
  • This systematic review analyzed 40 studies on digital interventions for BPD, including 6611 participants, to evaluate their effectiveness and the role of persuasive system design elements.
  • The review found that most interventions targeted symptoms like suicidal ideation (45%) and paranoia (13%), with the majority being randomized controlled trials (84%), highlighting the need for more focused research on the specific effects of these digital approaches on BPD symptoms.
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Otherwise known as debriefing the debrief, meta-debriefing describes the practice of debriefing simulation facilitators after they have facilitated, or observed, a debriefing. It is a vital component of enhancing debriefing skills, irrespective of where debriefers may be in terms of their professional development journey from novice to expert. We present the following 4 fundamental pillars, which underpin the creation of an impactful meta-debriefing strategy: theoretically driven, psychologically safe, context dependent, and formative in function.

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Article Synopsis
  • * Strengthening tuberculosis (TB) programs may provide a dual benefit, enhancing TB management while also improving readiness for future pandemics.
  • * Research indicates that countries with robust TB programs before COVID-19 managed the pandemic more effectively, with success linked to community trust, ongoing care, innovative responses, effective communication, and continued support for TB initiatives.
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Adoptive immunotherapy with Epstein-Barr virus (EBV)-specific T cells is an effective treatment for relapsed or refractory EBV-induced post-transplant lymphoproliferative disorders (PTLD) with overall survival rates of up to 69%. EBV-specific T cells have been conventionally made by repeated stimulation with EBV-transformed lymphoblastoid cell lines (LCL), which act as antigen-presenting cells. However, this process is expensive, takes many months, and has practical risks associated with live virus.

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Background: Low-dose aspirin is ineffective for primary prevention of cardiovascular events in people with body weight greater than 70kg. While the prevalent explanation for this is reduced platelet cyclooxygenase-1 (COX-1) inhibition at higher body weights, supporting data are limited, thereby demanding further investigation of the reason(s) underlying this observation. We propose that aspirin-mediated cyclooxygenase-2 (COX-2) acetylation and the resulting synthesis of 15-epi-lipoxin A, a specialized pro-resolving mediator, is suboptimal in higher weight individuals, which may contribute to the clinical trial findings.

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