Regulatory workshop on standardisation of clinical procedures, endpoints and data robustness of human challenge studies - A stakeholder meeting report.

Inno4Vac, a public-private partnership funded by the IMI2/EU/EFPIA Joint Undertaking (IMI2 JU), brings together academic institutions, SMEs, and pharmaceutical companies to accelerate and de-risk vaccine development. The project has made significant strides in the selection and production of challenge agents for influenza, respiratory syncytial virus (RSV), and toxigenic Clostridioides difficile for controlled human infection model studies (CHIMs). A regulatory workshop held on March 20, 2024, addressed the standardisation of clinical procedures, ethical considerations, endpoints, and data integrity, highlighting the ongoing initiatives related to these CHIMs.

SERS of nitro group compounds for sensing of explosives.

Detecting small concentrations of nitro-compounds surface-enhanced Raman spectroscopy (SERS) is reported. In particular, explosive analogues, such as 4-nitrophenol, 1-nitronaphthalene, and 5-nitroisoquinoline, and an explosive material (picric acid) are investigated and prepared by measurements using two different methods. One method involved mixing the analyte with plasmonic silver nanoparticles (Ag NPs) in a solution, followed by subsequent drop-casting of the mixture onto a silicon substrate.

From setbacks to success: lessons from the journey of RSV vaccine development.

Respiratory syncytial virus (RSV) causes high worldwide infant mortality, as well as a high disease burden in the elderly. Efforts in vaccine development over the past 60 years have recently delivered three approved vaccines and two monoclonal antibodies (mAbs). Looking back at the eventful history of RSV vaccine development, several factors can be identified that have hampered the developmental pathway, including the occurrence of enhanced RSV disease (ERD) in the first vaccine attempt and the difficulty in characterizing and stabilizing the pre-fusion F protein as a vaccine target.

Adaptation and validation of a quarter-of-life crisis questionnaire - The Developmental Crisis Questionnaire (DCQ-12).

Objectives: The aim of this article is to introduce the Polish adaptation of the Developmental Crisis Questionnaire (DCQ-12). In Poland, there is currently no tool for measuring the quarterlife crisis, hindering empirical exploration and cognitive understanding of this phenomenon. The DCQ-12, developed by Petrov and colleagues, serves as an age-independent measure of adult developmental crisis for research and applied purposes.