Publications by authors named "N Mazarakis"
Article Synopsis
- Neurophobia refers to the fear and anxiety that medical students and junior doctors experience regarding neurology and neurosurgery, leading to fewer students pursuing these specialties.
- A survey conducted with 264 medical students revealed that a significant number, 58% for neurology and 80% for neurosurgery, find these fields intimidating, highlighting a widespread issue across diverse medical schools globally.
- The study concludes that neurophobia is influenced by the complexities of neuroanatomy and neuropathology, and it can be exacerbated by negative clinical experiences.
Objectives: The immune response in children elicited by SARS-CoV-2 Omicron infection alone or in combination with COVID-19 vaccination (hybrid immunity) is poorly understood. We examined the humoral and cellular immune response following SARS-CoV-2 Omicron infection in unvaccinated children and children who were previously vaccinated with COVID-19 mRNA vaccine.
Methods: Participants were recruited as part of a household cohort study conducted during the Omicron predominant wave (Jan to July 2022) in Victoria, Australia.
Article Synopsis
- Researchers developed a 38-colour high dimensional immunophenotyping panel to analyze various immune cell subsets in peripheral blood mononuclear cells (PBMCs).
- This panel allows for the identification of innate and adaptive immune cells, including different T and B cell types, as well as assessing their activation status.
- Testing on PBMCs from 15 healthy adults showed that this tool is critical for studying immune cells in health and disease, especially when sample availability is restricted.
Objective: Soluble CD27 is a promising cerebrospinal fluid inflammatory biomarker in multiple sclerosis. In this study, we investigate relevant immune and neuro-pathological features of soluble CD27 in multiple sclerosis.
Methods: Protein levels of soluble CD27 were correlated to inflammatory cell subpopulations and inflammatory cytokines and chemokines detected in cerebrospinal fluid of 137 patients with multiple sclerosis and 47 patients with inflammatory and non-inflammatory neurological disease from three independent cohorts.
High grade gliomas are the most common primary aggressive brain tumours with a very poor prognosis and a median survival of less than 2 years. The standard management protocol of newly diagnosed glioblastoma patients involves surgery followed by radiotherapy, chemotherapy in the form of temozolomide and further adjuvant temozolomide. The recent advances in molecular profiling of high-grade gliomas have further enhanced our understanding of the disease.
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