Publications by authors named "N Matthew Decker"
Objective: To investigate retinal vascular permeability mapping as a potential biomarker for diabetic retinopathy in subjects with diabetes with no signs of retinopathy and with mild nonproliferative retinopathy.
Design: This is a case-control study.
Subjects: Participants included 7 healthy controls, 22 subjects with diabetes mellitus and no clinical signs of retinopathy (DMnoDR), and 7 subjects with mild nonproliferative diabetic retinopathy (NPDR).
Purpose: The foveal avascular zone (FAZ) area has been explored as a measure of macular ischemia in diabetic retinopathy (DR) but is limited by its wide variability even in healthy individuals. We hypothesized that FAZ enlargement, which we defined as the difference between the functional FAZ (on optical coherence tomography angiography; OCTA) and structural FAZ (en face OCT), may be a more accurate metric of macular ischemia. In this study, we test the hypothesis that FAZ enlargement is associated with decreased best-corrected visual acuity (BCVA) and low luminance visual acuity (LLVA) and performs better than the functional FAZ as a marker of vision loss.
View Article and Find Full Text PDFPurpose: To evaluate the reliability of clinical grading of diabetic retinopathy (DR) severity compared with grading on ultra-widefield pseudocolor fundus (UWF-CF) and ultra-widefield fluorescein angiography (UWF-FA) images and their relative detection of sight-threatening DR and referable DR.
Methods: A total of 184 diabetic eyes were analyzed. UWF-CF and UWF-FA images were graded based on the International Clinical Diabetic Retinopathy severity scale.
We previously showed that macrophage-like cells (MLCs) are increased in eyes with advanced diabetic retinopathy (DR). Here, we hypothesized that MLC density was correlated with ischemia using optical coherence tomography angiography (OCTA) and ultra-widefield fluorescein angiography (UWF-FA). Treatment-naïve diabetic eyes were prospectively imaged with repeated OCTA (average 5.
View Article and Find Full Text PDFArticle Synopsis
- - This study analyzed the relationship between cholesterol precursors and oxysterols in 2,282 women with breast cancer, considering various factors like lifestyle, health conditions, and tumor characteristics.
- - Key findings showed that obesity was significantly linked to increased levels of specific sterols, while cardiovascular comorbidities influenced levels of certain sterols differently.
- - The research suggests that while cholesterol precursors are closely related to metabolic factors, oxysterols are more associated with the characteristics of breast cancer tumors, indicating a need for further investigation.