Removable dialkoxybenzyl linker for enhanced HPLC purification of peptide hydrazides.

High-performance liquid chromatography (HPLC) plays a crucial role in purifying peptides and proteins and monitoring their reactions. Peptide hydrazides are widely employed intermediates in modern peptide/protein chemistry. However, they often exhibit peak tailing during HPLC purification and analysis.

Continuous-Flow Ritter Reaction for Sustainable Amide Synthesis Using a Recyclable -Phenolsulfonic Acid-Formaldehyde Resin Catalyst.

Herein, a rapid and efficient continuous-flow synthesis of amides is described. The Ritter reaction, catalyzed by a reusable solid acid catalyst composed of -phenolsulfonic acid-formaldehyde resin (PAFR II), was used to convert nitriles and alcohols to amides in up to 90% yield. The continuous-flow system facilitates short reaction times and maintains activity for several weeks.

Effect of ultrafine CO2 bubbles on Euglena gracilis Z growth with CO2 gas bubble size and chlorophyll content.

Microalgae have been explored as a viable alternative food source. Among them, Euglena gracilis stands out as a promising single-cell algae. However, the challenge lies in developing more efficient and cost-effective methods for industrial mass production of Euglena gracilis under controlled culture conditions.

Identification of peptide-based hepatitis B virus capsid inhibitors based on the viral core protein.

In this study, we have identified two novel peptides, 19Ac (comprising residues 91-105) and 20Ac (encompassing residues 96-110), from a systematically designed peptide library based on the Hepatitis B virus (HBV) core protein, that inhibit the assembly of HBV capsid. Peptide 20Ac exhibited about twofold the inhibitory potency of 19Ac and proved effective against both standard and morphothiadin (GLS4)-resistant HBV strains. Molecular dynamics simulations revealed that despite their overlapping sequence, 19Ac and 20Ac bonded to different regions of the core protein, thereby inhibiting capsid assembly through distinct mechanisms.

Tetrahydroisoquinolines - an updated patent review for cancer treatment (2016 - present).

Introduction: Cancer is a prominent cause of death globally, triggered by both non-genetic and genetic alterations in genes influenced by various environmental factors. The tetrahydroisoquinoline (THIQ), specifically 1,2,3,4-tetrahydroisoquinoline serves as fundamental element in various alkaloids, prevalent in proximity to quinoline and indole alkaloids.

Area Covered: In this review, the therapeutic applications of THIQ derivatives as an anticancer agent from 2016 to 2024 have been examined.