Publications by authors named "N Marin"

Drinking and wastewater are to be treated for safe human consumption and for keeping surface waters clean. There are multiple water purification procedures, but the use of ion-exchange resins significantly enhances water purification efficiency. This review was targeted on highlighting the concept and classification of polymeric ion-exchange resins as well as pointing out their real-world applications.

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Sewage sludge (SS) resulting from wastewater treatment plants (WWTP) is commonly applied worldwide as a fertilizer in agriculture. This can be done following a rigorous analysis of the sewage sludge composition. Due to its toxic potential, heavy metal ion content is one of the key parameters to test when evaluating SS sample usage as fertilizer.

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Background: Helicobacter pylori is a prevalent infection that may complicate pregnancy, but evidence remains limited, controversial and may not apply to all pregnant women.

Objective: This study aims to evaluate whether Helicobacter pylori is a risk factor for adverse pregnancy outcomes and to identify vulnerable subpopulations.

Study Design: Multiplex serology was utilized to measure blood levels of immunoglobulin G against eight Helicobacter pylori antigens in 1372 pregnant women from three European birth cohorts: BiB (United Kingdom), Rhea (Greece) and INMA (Spain).

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Activation of natural killer (NK) cells with the cytokines interleukin-12 (IL-12), IL-15, and IL-18 induces their differentiation into memory-like (ML) NK cells; however, the underlying epigenetic and transcriptional mechanisms are unclear. By combining ATAC-seq, CITE-seq, and functional analyses, we discovered that IL-12/15/18 activation results in two main human NK fates: reprogramming into enriched memory-like (eML) NK cells or priming into effector conventional NK (effcNK) cells. eML NK cells had distinct transcriptional and epigenetic profiles and enhanced function, whereas effcNK cells resembled cytokine-primed cNK cells.

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Article Synopsis
  • CD8α is a receptor found on a variable percentage of human NK cells, and its role in NK cell function is not well understood, especially in the context of leukemia treatment.
  • Studies showed that CD8α- NK cells effectively controlled leukemia in models, likely due to better proliferation, whereas CD8α+ NK cells were associated with poorer therapeutic outcomes.
  • IL-15 stimulation led to the induction of CD8α on previously CD8α- NK cells, enhancing their proliferation and activity, with CD8A deletion showing potential to boost NK cell activity by affecting the balance of activating and inhibitory receptors.
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