Publications by authors named "N Marchetti"
Background: The efficacy and safety of ensifentrine, a novel PDE3/PDE4 inhibitor, were previously evaluated in the ENHANCE-1 (NCT04535986) and ENHANCE-2 (NCT04542057) trials. Here, we present a pooled post-hoc subgroup analysis of patients according to background chronic obstructive pulmonary disease (COPD) maintenance medication regimens.
Objective: This analysis aimed to explore the efficacy and safety of ensifentrine in patients receiving long-acting muscarinic antagonists (LAMA) or long-acting beta-agonists with inhaled corticosteroids (LABA + ICS).
Hepatic Sinusoidal Obstruction Syndrome (SOS) Associated with Checkpoint Inhibitor Therapy.
Eur J Case Rep Intern Med
December 2024
Unlabelled: Sinusoidal obstruction syndrome (SOS) is a distinctive and potentially fatal form of hepatic injury that mainly occurs after hematopoietic-stem cell transplantation but also due to many other conditions including drug or toxin exposure. Recently, immune checkpoint inhibitors (ICIs) have revolutionised the treatment of many solid organ malignancies. Furthermore, as their use has become more widespread, rare toxicities have emerged.
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- - Alveolar type II (ATII) cells play a critical role in lung repair but their damage, often caused by cigarette smoke, contributes to the onset of emphysema, marked by destruction of alveolar walls.
- - Researchers examined ATII cells from non-smokers, smokers, and emphysema patients, focusing on the protein PICT1 and its role in disease progression, using both human cell analysis and a murine model.
- - Findings revealed decreased PICT1 levels in emphysema, linked to reduced DNA damage repair capabilities and mitochondrial dysfunction, suggesting that targeting PICT1 could lead to new treatments for the disease.
Article Synopsis
- Point of Care Ultrasound (POCUS) is used to assess pleural movement in patients with advanced emphysema, but its effectiveness in these patients is not well established.
- A study evaluated ultrasound findings in 48 COPD patients and found a significant number showed abnormal patterns, such as absent lung sliding or a barcode appearance.
- Results indicated there is limited correlation between ultrasound abnormalities and standard lung function measures, highlighting a need for cautious interpretation of POCUS in these cases.
Impaired alveolar epithelial regeneration in patients with idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) is attributed to telomere dysfunction in type II alveolar epithelial cells (ACs). Genetic susceptibility, aging, and toxicant exposures, including tobacco smoke (TS), contribute to telomere dysfunction in ACs. Here we investigated whether improvement of telomere function plays a role in CSP7-mediated protection of ACs against ongoing senescence and apoptosis during bleomycin (BLM)-induced pulmonary fibrosis (PF) as well as alveolar injury caused by chronic TS exposure.
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