Bidirectional negative relationship between thyrotropin and kidney function during alcohol intoxication in males.

Introduction: Despite a well-established direct toxic effect of alcohol on renal cells, there is a salutary dose-dependent effect of alcohol consumption on common laboratory parameters related to kidney performance. Alcohol also impacts thyroid hormones, while thyroid status modulates kidney function. The modulation of kidney parameters with thyrotropin (TSH) and thyroid status indicates a possible interaction between alcohol, kidney, and thyroid functions.

HPV, oropharyngeal cancer, and the role of the dentist: a professional ethical approach.

Human papillomavirus (HPV) is an emerging risk factor for oropharyngeal cancer, especially among younger patients, and must be thoughtfully addressed by the dental community. The professional ethical decision-making model first advanced by Ozar and Sokol for use by dentists at chairside (define the dilemma, assess the facts, identify and rank the alternatives, and choose a course of action) was modified to delineate clearly inputs, considerations, and feedback loops based on what is professionally and ethically at stake in advising patients. As the link between HPV and oropharyngeal cancer is established through scientific studies, the role of the dentist in primary and secondary prevention will be crucial.

Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease.

Background: Common autoimmune disorders tend to coexist in the same subjects and to cluster in families.

Methods: We performed a cross-sectional multicenter study of 3286 Caucasian subjects (2791 with Graves' disease; 495 with Hashimoto's thyroiditis) attending UK hospital thyroid clinics to quantify the prevalence of coexisting autoimmune disorders. All subjects completed a structured questionnaire seeking a personal and parental history of common autoimmune disorders, as well as a history of hyperthyroidism or hypothyroidism among parents.

Prediction of cure and risk of hypothyroidism in patients receiving 131I for hyperthyroidism.

Context: There is little consensus regarding the most appropriate dose of radioiodine ((131)I) to be administered to patients with hyperthyroidism.

Objective: To compare the efficacy of fixed dose regimens of (131)I in curing hyperthyroidism and to define simple clinical and biochemical factors that predict outcome in individual patients.

Design: Consecutive series of hyperthyroid subjects treated with (131)I.

Influences of age, gender, smoking, and family history on autoimmune thyroid disease phenotype.

Context: Both genetic and environmental factors contribute to susceptibility to Graves' disease (GD) and Hashimoto's thyroiditis (HT), as well as disease manifestations.

Objective: The objective of the study was to define how endogenous/environmental factors contribute to variation in phenotype.

Design/setting: This was a multicenter cohort study.